Pulsatile delivery helps in providing the drug at an exact moment based on the disease's pathophysiology that cause improved patient therapeutic efficacy. Drug release rapidly after specific lag time this are advantage for many diseases condition. This system is designed according the body's circadian rhythm and after a lag time, the medication is released fast and totally as a pulse. Pulsatile delivery systems helpful in disease include asthma, arthritis, attention deficient syndrome, peptic ulcer and hypercholesterolemia. These systems are useful for diseases with chrono pharmacological behavior that necessitate nighttime administration, medications with a high first pass effect or GIT site specific absorption, and drugs with a high risk of toxicity or tolerance. By reducing dosing frequency, these devices help increase patient compliance. The foundation for this article is the disease that treat by pulsatile delivery system with drug used for specific disease condition and chrono pharmacology of all disease that mention in article.

The ‘in situ gel’ system has appeared as one of the most effective drug delivery systems. Its specific distinguishing feature of 'Sol to Gel' transition aids in the continuous and controlled release of medicines. These systems have a number of advantages, including simple production, convenience of use, enhanced adherence, and patient comfort by lowering drug delivery frequency due to their distinctive sol to gel transition characteristics. An in-situ gelling system is a formulation that is in solution form before penetrating the body but transforms to gel form under specified physiological conditions. This review mainly focused on introduction, Advantages and Disadvantages of in situ gel, mechanism, types of Polymers used, Evaluation of in situ gel and its applications.

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The current investigation was developed to study the role of functionalized guar gum as carrier in solid dispersion of iboprofen. The solid dispersion technique using aminated guar gum would be an effective approach for increasing the solubility and increasing dissolution behaviour of ill fathomable medicament than the native guar gum. The results of FTIR and DSC studies confirmed that there is no chemical interaction or no incompatability between the drug and excipients. The invitro dissolution study was performed for the the prepared formulations. Based on the results SD3 was shown highest drug release 99.41% within 24hrs. Stabiliy study was conducted as per ICH guidelines and the falloutsrevealed that there is no physical or chemical change.it may be concluded that solubility of ibuprofen can br improved by using functionalized guar gum in the solid dispersion, which provides a wide scope for the therapeutic efficiency.

Microsponges drug delivery system composed of porous microsphere. They are tiny sponges-like spherical particles with a larger porous surface. Morever they may enhance stability, reduce side effect and modify drug release favorably. Microsponges technology has many favorable characteristics, which make it a versatile drug delivery system. Microsponge system are based on microscopic, polymer-based microsphere that can suspend or entrap a wide variety of substance, and it can be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing a sustained floe of substance out of the sphere. Microsponges are designated to deliver a pharmaceutical active ingredient efficiently at the minimum dose and also to enhance stability, reduce side effect, and modify drug release.