ABSTRAKSalah satu tanaman yang memiliki kandungan imunostimulator yaitu bawang dayak (Eleutherine palmifolia (L.) Merr.). Ekstrak etanol umbi bawang dayak (EEUBD) memiliki kandungan fitokimia yang bersifat sebagai antioksidan antara lain triterpenoid, flavonoid, fenolik, alkaloid dan tanin. Flavonol berpotensi sebagai imunostimulan meningkatkan produksi IL-2 yang terlibat dalam aktivasi dan proliferasi sel T. Flavonoid dapat menginduksi Th1 untuk menghasilkan IFN- γ, IFN- γ berperan untuk menginduksi sel limfosit B memproduksi imunoglobulin. Untuk mengetahui potensi pengaruh pemberian ekstrak etanol umbi bawang dayak dalam pencegahan penurunan diameter germinal center pada kelenjar getah bening serta pencegahan penurunan kadar Ig G serum pada mencit yang diinduksi metilprednisolon oral dilakukan penelitian dengan desain eksperimental. Pada penelitian ini mencit dikelompokkan menjadi lima kelompok yaitu kelompok I (K1) merupakan perlakuan kontrol hanya diberi CMC Na+ 0,5 %. Kelompok II (K2) merupakan model imunosupresi yaitu kelompok perlakuan yang diinduksi metilprednisolon 0,08 mg/30 grBB mencit/ hari terlarut dalam 0,2 ml aquades. Kelompok III (K3) dengan perlakuan metilprednisolon ditambah EEUBD dengan dosis 50 mg/kgBB. Kelompok IV (K4) dengan perlakuan metilprednisolon ditambah EEUBD dengan dosis 100 mg/kgBB dan kelompok V (K5) dengan perlakuan metilprednisolon ditambah EEUBD dengan dosis 200 mg/kgBB, diberikan sekali sehari selama 14 hari bersamaan pemberian induksi metilprednisolon pada sore hari secara per-oral (sonde intragastrik). Kemudian diamati peningkatan diameter germinal center dan kadar Ig G serum. Data hasil penelitian antar kelompok dianalisis dengan menggunakan uji korelasi bivariat koefisien pearson. Hasil penelitian menunjukkan bahwa EEUBD terbukti sebagai imunostimulator terhadap peningkatan diameter germinal center pada dosis 100 mg/kgBB dan peningkatan kadar Ig G serum pada dosis 200 mg/kgBB.Kata-kata kunci : bawang dayak (Eleutherine palmifolia (L.) Merr.), germinal center, imunoglobulin G (Ig G)
Latar Belakang : Dismenore primer sering terjadi pada remaja karena hormon yang dihasilkan belum stabil. Prevalensi dismenore primer pada remaja Indonesia adalah 60-75%. Aktivitas fisik adalah salah satu faktor resiko terjadinya dismenore primer. Aktivitas fisik remaja menurun setiap tahun. Tujuan : Literature review ini bertujuan menganalisis hubungan antara aktivitas fisik dengan dismenore primer pada remaja. Metode: Mesin pencarian data yang digunakan adalah Google Scholar, Science Direct, dan Garuda. Jurnal yang dikumpulkan adalah jurnal nasional dan internasional sejak tahun 2015-2020. Pencarian artikel penelitian ini menggunakan kriteria inklusi dan eksklusi. Literature review ini menggunakan 15 jurnal nasional dan 8 jurnal internasional. Hasil : Jurnal yang menyatakan aktivitas fisik berhubungan dengan dismenore primer pada remaja ditemukan sebanyak 21 jurnal, sedangkan 2 jurnal menyatakan tidak berhubungan. Aktivitas fisik meningkatkan endorphin, memperlancar aliran darah kebagian genital, dan meningkatkan vasodilatasi pembuluh darah. Kesimpulan: Aktivitas fisik berhubungan dengan dismenore primer pada remaja.
People in Central Borneo which is often used to treat diarrhea is the fruit of masisin (Rhodomyrtus tomentosa Wight) with active compounds which are capable to treat diarrhea such as alkaloids, flavonoids, tannins, saponins, and steroids. Diarrhea is a defecate with a liquid or half-liquid feces, the content of water in a feces is more than usual, it is more than 200 g or 200 ml / 24 hours. To know the effectiveness of the extract of the fruit of masisin as an alternative to antidiarrheal treatment seen from the frequency, duration, and consistency of feces in male white mice (Mus musculus). This study design was a true experimental design with post-test control group design with 5 treatments for each group. This study started by making some extracts of Masisin fruit. Followed observation with 5 treatment groups animals. The induction of diarrhea was using oleum ricini, with aquadest as the negative control, and Loperamide HCL as the positive control. The dose of ethanol extracts of masisin fruit divided into 0.3 mg/g BW, 0.6 mg/g BW and 1.2 mg/g BW, all of the treatments were given orally. This study data was statistically analyzed with one way ANOVA. The results of one way ANOVA test showed that the value of p <0,05 meaning that there is the influence of EEBM on frequency, consistency and duration of diarrhea at doses 0.3 mg/g BW, 0.6 mg/g BW and 1.2 mg/Gbw. Based on observations ethanol extracts of masisin fruit had antidiarrheal effect at doses 0,3 mg/g BW, 0.6 mg/g BW and 1.2 mg/g BW in male white mice (Mus musculus).
Attention deficit hyperactivity disorder (ADHD), a neurobehavioral disorder that most often occurs in children, is a condition that affects school-age children as a mental disorder. One of the therapies that can be used is integrated sensory therapy with a form of therapy that encourages a child to develop their physical abilities. Search this article to see the relationship of integrated sensory therapy to changes in behavior and concentration of children with ADHD (Attention Deficit Hyperactive Disorder). Searching for articles through google scholar, found 18 journals to be reviewed. There were several games that had a relationship between sensory therapy, integration of behavior changes and concentration of children with ADHD, short-term play increased children's concentration, guessing the contents of the glass increased children's concentration and behavior, socialization games decreased impulsive behavior, bowling increased children's concentration, game education, increased concentration play children, PECS (Picture Exchange Communication System) increases children's concentration, mazes increase concentration, cranks increase children's concentration, flashcards increase concentration, music increases concentration and decreases impulsive behavior and writing increases concentration and decreases impulsive behavior. There is 1 journal which states that there is no difference between the integrated sensory therapy group and the untreated sensory integration group. There is a relationship between integrated sensory therapy to behavior change and control of children with ADHD. Integration sensory therapy involves activities that manage the sensory system by providing vestibular, proprioceptive, auditory, and touch input so that it can reduce hyperactive behavior and increase constructive behavior in children with ADHD.
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