Introduction Abdominal aortic aneurysm AAA is a vascular disease characterized by chronic inflammation in the vascular wall and progressive dilation of the abdominal aorta. Previous reports indicated that the development of AAA is associated with advanced age, male sex, smoking, and hypertension 1, 2. The mortality rate due to AAA rupture is very high, and therapeutic drugs to prevent the progression and rupture of AAA have not been established 3. The development of AAA involves various factors 4 6 , including the weakening of the vascular walls due to inflammation and the degradation of fibers. Immune cells, such as monocytes and macrophages, release inflammatory cytokines, including monocyte chemoattractant protein-1 MCP-1 and tumor necrosis factor-α that activate matrix metalloproteinases MMPs 7. Consequently, MMPs degrade the elastin and collagen fibers that play an integral role in the
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