Uncommon neurological diseases make for roughly half of all rare diseases. As one of the key players in the diagnostic process, neurologists require guidelines on the types of screening tests that can be done. In this sense, biomarker research has been very active. By minimizing the chance of misdiagnosis and improper therapy, diagnostic biomarkers may help reduce the risk of disease progression. Also, Neurological complications and associated radiological findings have been reported in an increasing number of patients with COVID-19 infection. Despite improved methods, diagnosing CNS inflammatory diseases is still difficult and time-consuming. Although MRI is essential in this procedure, it might be confusing in some circumstances due to overlapping radiological results. Considering the above facts, the necessity for specialized biomarkers seems to be paramount. Serological markers appear to merit special consideration. Peripheral blood samples, unlike CSF, are easily obtained in routine ambulatory care for many periods, allowing noninvasive monitoring of therapy response. A complete combination of clinical examination, radiographic assessment, laboratory tests, and often a multidisciplinary approach is required to make an accurate diagnosis.

Diabetic peripheral neuropathy (DPN) is a frequent complication of DM. Advanced DPN can lead to major problems such as diabetic foot ulcers. Early identification of DPN cases will benefit early therapy and motivate patients to participate in their care actively. Early diagnosis is critical to improving prognosis and quality of life for people with DPN. This is due to the absence of symptoms in 50% of patients and the limited sensitivity of neuro-electrophysiology to small fibers. Many studies have shown that high-resolution ultrasound (HRU) is a good noninvasive method for diagnosing DPN. With modern technologies, HRU may be used to screen, diagnose, and monitor DPN, acting as a biomarker and giving novel diagnostic insights The electrodiagnostic alteration in DPN is preceded by morphological abnormalities on ultrasonography. High-resolution ultrasonography of peripheral nerves has the potential to become the first-line study for the diagnosis of DPN. This review work studies the diagnostic Role of High-Frequency Ultrasound in Diabetic Neuropathy