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IOS has shown a highly significant association with spirometric indices and reversibility testing. It may be a substitute for spirometry in children who fail to perform forced expiratory maneuvers.

No abstract

ÖzETAmaç: Kronik ürtikerin etiyolojisi çoğunlukla idiyopatiktir. Çocukluk çağı kronik ürtikeri ile ilgili literatürde sınırlı veri mevcuttur. Çalışmada, çocuklarda kronik ürtikerin etiyolojisinde rol oynayabilecek faktörler ve ilişkili klinik ve laboratuvar bulguların araştırılması amaçlandı. Gereç ve Yöntemler:Kliniğimizde kronik ürtiker tanısı alan 18 yaş altı 80 hasta retrospektif olarak incelendi. Kronik ür-tikerli hastaların klinik özellikleri, laboratuvar bulguları, atopi, enfeksiyon, otoimmünite ve fiziksel ürtikere yönelik tetkikleri değerlendirildi. Bulgular:Kronik ürtiker tanısı ile izlenen 80 hasta çalışmaya dahil edildi. Hastaların ortalama yaşı 10.2±4.1 yıldı. 41'i (%51.2) kızdı. Hastaların %53.7'sinde fiziksel ürtiker, %46.3'ünde kronik spontan ürtiker tesbit edildi. En sık saptanan komorbid hastalıklar sırasıyla; otoimmün hastalık (%10) (5 otoimmün tiroidit, 1 juvenil romatoid artrit, 1 diyabet, 1 akut romatizmal kardit), kronik gastrit veya reflü (%8.7) ve nonsteroidal anti-inflamatuvar ilaç (NSAİ) allerjisi (%5) idi. Kronik ürtikerli hastaların %23.7'sinde atopi, %16.4'ünde helikobakter pylori pozitifliği, %20.3'ünde tiroid otoantikor varlığı, %33.3'ünde antinükleer antikor (ANA) pozitifliği, %25'inde gıda katkı maddesi ile ilişkili ürtiker, %6.7'sinde dışkıda parazit saptandı. Otolog serum deri testi pozitifliği (OSDT) %37.8 olarak bulundu. OSDT pozitif (n=14) ve negatif (n=23) hastalar karşılaştırıldığında; yaş, cinsiyet, atopi, otoimmün hastalık varlığı, ANA pozitifliği, tiroid otoantikor varlığı ve Helikobakter pylori pozitifliği açısından gruplar arasında anlamlı bir fark saptanmadı. Fiziksel ürtiker nedenleri arasında en sık dermografizm (%45) görülürken, %32.4'ünde kolinerjik ürtiker, %8.7'sinde gecikmiş basınç ürtikeri, %8'inde soğuk ürtiker ve %4.7'sinde solar ürtiker tesbit edildi.Sonuç: Çocuklarda kronik ürtiker etiyolojisinde otoimmünite ve fiziksel ürtiker önemli bir yer tutmaktadır. Şüpheli olgularda fiziksel ürtiker testlerinin ve ayrıntılı incelemelerin yapılması kronik ürtikerli olguların daha iyi bir şekilde yönetimine katkı sağlayacaktır.Anahtar Sözcükler: Antinükleer antikor, Çocuklar, Helikobakter pylori, Kronik ürtiker, Otoimmün tiroidit, Otolog deri testi ABSTRAcTObjective: The etiology of chronic urticaria is usually considered idiopathic. There is limited data regarding childhood chronic urticaria in the literature. The aim of the study was to investigate the factors that can play a role in the etiology of chronic urticaria in children and the related clinical and laboratory findings. Material and Methods:We retrospectively evaluated the medical records of 80 children aged under 18 years who attended our clinic and were diagnosed with chronic urticaria. Clinical characteristics, laboratory findings and tests for atopy, infection, autoimmunity and physical urticaria were evaluated.Results: Eighty children with chronic urticaria were enrolled in the study. The mean age of the patients was 10.2±4.1 years. 41 (51.2%) of the patients were female. Of the study population, 46.3...

Background: The effectiveness of montelukast for wheezing in young children is not clear. We aimed to evaluate whether the use of montelukast in the treatment of wheezing affects the number of attacks in children aged 1 to 6 years. Methods: This is a single center study. It was conducted between August 2019 – 2020. Children with aged 0-6 years old with a wheezing complaint who applied to the pediatric allergy and immunology outpatient clinic were included in the study. Modified asthma predictive index of the patients were evaluated. It was classified as episodic viral wheezing (EVW) or multiple trigger wheezing (MTW) based on the type of wheezing. Montelukast treatment was started and the number of attacks was checked. Results: The total of 141 children who applied with wheezing complaints were included in the study. The majority of the patients were boys (n=99). The mean age of the children was 4.2 ± 1.5 years. The median number of attacks before treatment was 2 (2-3). In 2.8% of the patients, eczema, in 12.8% of them, rhinitis and in 26.7% of them, elevated eosinophils were detected. IgE levels were 148.25 ± 279.20 IU/mL. According to the number of attacks before treatment, there was a significant decrease in the number of attacks in the control (p <0.001). Conclusion: In this study, montelukast has been shown to reduce the number of EVW attacks and we believe montelukast may be a potential treatment option for EVW in preschool children.