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In our present study, we have developed a new, endophytic mediated technique for the synthesis of gold nanoparticles (AuNPs) from the endophytic fungus Alternaria spp. extract isolated from Rauvolfia tetraphylla root. The synthesized AuNPs were characterized using Ultraviolet-visible spectroscopy (UV-vis), Energy Dispersive x-ray Spectroscopy (EDX) and Transmission Electron Microscopy (TEM) thoroughly. It has been confirmed as the variable shapes accompanied average particle size of 28 nm. Further, the characterized AuNPs were screened for their antibacterial activity against Gram positive bacteria Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia and Gram negative bacterium Staphylococcus aureus. The synthesized AuNPs were tested for antioxidant, antibacterial and antimitotic activities. The AuNPs showed considerable antibacterial, antioxidant and antimitotic activities. It is a novel method to report the synthesis of AuNPs using Rauvolfia tetraphylla based endophytic extract as a reducing agent.

The field of nanotechnology is the most promising area of the research. In our present study we report the biological method of synthesis of silver nanoparticles by endophytic extracts isolated from the leaf of Simarouba glauca. The surface Plasmon resonance characteristic of silver nanoparticles was revealed by the UV-Vis spectrum at 400 nm. The crystalline nature of silver nanoparticle was confirmed by X ray diffraction studies. Spherical shaped and monodispersed nanoparticles were found in Scanning electron micrograph. The average size of silver nanoparticles was 41.9 nm as determined by dynamic light scattering. The peak in silver region confirming the presence of elemental silver was determined by Energy dispersive X-ray spectroscopy analysis. Antibacterial activity of silver nanoparticles utilized in this study was found to be more significant than standard Taxim antibiotic against multidrug resistant bacteria such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumonia. Endophytic based silver nanoaprticles were found to possess significant antioxidant activity.