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The goal of the following article is to show that the system of values (ideals and worldview attitudes) affects the nature and results of scientific work of a researcher. It is showed, that socio-cultural and historical conditionality of scientific knowledge is implemented not only by the impact of social institutions, investment policy and state support for science, but also through the system of value orientations of scientists themselves. It was analyzed the axiological views in the application of scientific knowledge to such prominent outstanding thinkers such as I. Kant, H. Rickert, M. Weber, W. Dilthey. We prove that an approach which recognizes that the values in science express socio-cultural conditioning of science, and becomes the determining factor in philosophy of social and humanitarian knowledge. Keywords: axiology, value, cognition, meaning, social and humanitarian cognition, truth as a value