Horizontal transmission of turkey herpesvirus (HVT) was studied in three separate trials using three different lines of chickens in each trial. There was no horizontal spread of HVT to contact cagemates through 8 weeks regardless of the line of donor chickens, when inoculated subcutaneously with 9.2 times 10-3 plaque-forming units (PFU) of HVT at 1 week of age. The virus spread poorly to a few cagemates from an experimental line of White Leghorns (W.S.U.-V.S.), but not from a commercial line of White Leghorns (C.-W.L.) or meat-type (C.-M.T.) chickens, when inoculated with 9.4 times 10-4 PFU of HVT at 1 week of age. The virus spread readily to contact cagemates from W.S.U.-V.S. but not at all from C.-W.L. or C.-M.T. chickens when inoculated with 2 times 10-4 PFU of HVT at 8 weeks of age. The incidence among cagemates of contact infection by HVT appeared similar regardless of genetic lines. This observation indicated a difference among different genetic lines of chickens in the development and/or shedding of infectious HVT following virus inoculation.

Airborne transmission of turkey herpesvirus (HVT) between chickens was studied in two trials using an experimental line of White Leghorns. HVT either did not spread or spread poorly to chickens that had been exposed for 8 weeks to the exhaust air from a cage containing donor chickens inoculated with HVT at 8 weeks of age. There was no airborne transmission of HVT to chickens that had been exposed for 4 weeks. This study indicated a possible by an infrequent spread of HVT between chickens via airborne route.

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A cytopathic agent was isolated and characterized as an isolate of Marek's disease herpesvirus (MDHV) with low pathogenicity, and referred to as the HN isolate. This isolate of MDHV did not cause clinical Marek's disease (MD) or death in a highly susceptible line of chickens within 5 weeks after exposure. Gross lesions of limited extent were noted in a few of the inoculated birds. Microscopic nerve lesions in the inoculated and contact-infected birds were invariably minimal, closely resembling C-type MD lesions.

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