Background:Allergic reactions occur commonly in transfusion practice. However, severe anaphylactic reactions are rare; anti-IgA (IgA: Immunoglobulin A) in IgA-deficient patients is one of the well-illustrated and reported causes for such reactions. However, IgE-mediated hypersensitivity reaction through blood component transfusion may be caused in parasitic hyperimmunization for IgG and IgE antibodies.Case Report:We have evaluated here a severe anaphylactic transfusion reaction retrospectively in an 18year-old male, a known case of cerebral malaria, developed after platelet transfusions. The examination and investigations revealed classical signs and symptoms of anaphylaxis along with a significant rise in the serum IgE antibody level and IgG by hemagglutination method. Initial mild allergic reaction was followed by severe anaphylactic reaction after the second transfusion of platelets.Conclusion:Based on these results, screening of patients and donors with mild allergic reactions to IgE antibodies may help in understanding the pathogenesis as well as in planning for preventive desensitization and measures for safe transfusion.

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BACKGROUNDABO system remains the most important blood group system in transfusion and organ transplantation medicine. ABO typing and ABO incompatibility testing remain the foundation of all pretransfusion testing. An inverse reciprocal relationship exists between the presence of A and B antigens on red cells and the presence of Anti-A and Anti-B or both in sera. Discrepancies in ABO grouping can be characterised by inappropriate results in either cell or serum grouping.The aim of this study is to analyse commonly occurring ABO group discrepancies in order to standardise resolving procedure and avoid delay in pretransfusion testing.

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