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The acute toxicities of thirteen new esters of gentisic acid and that of gentisic acid have been determined by the intravenous injection of the com unds into white mice. The results are integrated by Behren's method. The 3 -~t h y l a m i n o p r o p y I esters of gentisic acid are more toxic generally than the 2-diethylaminoethyl counterparts. The 3-diethylaminopropyl-5-methoxy salicylate hydrochloride is the most toxic of the new esters. The increase in toxicity of the hydrochlorides of the esters of gentisic acid and amino alcohols over gentisic acid apparently is due chiefly to the dialkylaminoalkyl group. Esters of gentisic acid and other carboxylic acids are more toxic than gentisic acid because of the inherent toxicity of the carboxylic acids. These compounds are less toxic than the esters of gentisic acid and amino alcohols because they are less soluble in aqueous media.