The current study investigates the effect of fraction IV portion of Ximenia americana stem bark on Trypanosoma congolense induced serum enzymes changes in rats. Following infection with trypanosomes, the rats were monitored for levels of some serum enzymes. The results revealed that there was significant (P<0.05) elevation of serum enzymes Aspartate AminoTransferase (AST), Alanine AminoTransferase (ALT), Alkaline Phosphatase (AP), Gamma GlutamylTransferase (GGT) and Creatine Kinase (CK) in the infected animals. Treatment with 25 mg/Kg body weight fraction IV portion of Ximenia americana led to significant (P<0.05) reduction in levels of the enzymes. It is concluded that treatment with fraction IV portion of Ximenia americana was able to modulate the effect of trypanosomosis induced serum enzyme levels of the infected rats.

Ximenia americana is endemic in Northern Nigeria, and has been reported to be used in treatment of various types of ailments. In the present study, the antimicrobial properties of the stem bark extracts of Ximenia americana were screened against Escherichia coli, P.aeruginosa, Staphylococcus aureus, P. vulgaris, Candida albicans, B. subtilis using the disc diffusion method. The result revealed the methanolic and water extract showed significant (P<0.05) broad spectrum activity on the growth of many of the test organisms (E. coli, and P. vulgaris, S.aureus, P. aeruginosa and B. subtilis), while the butanolic extract had little activity. Phytochemical screening revealed the presence of alkaloids, saponins, flavonoids, cardiac glycosides, terpenoids and tannins. The study supports the traditional usage of this plant by herbalist as remedy in curing microbial infections.