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The study of magnetic nanoparticles (MNPs) is an emergent field of science in this era due to their widespread utilization in the various fields of biomedical science. Developing concerns of magnetic nanoparticles in the researcher’s field led to design a huge number of MNPs including individual or binary metallic particles, oxides, (ferrites), biopolymer coated composites, metallic carbides and graphene mediated nanoparticles. Numerous synthetic routes are defined in literature to attain the desired size, crystal structure, morphology and magnetic properties. To build up biocompatibility, MNPs subjected to surface treatments by coating with some suitable organic or inorganic biomaterials which not only improves its physical characteristics but also elevate its chemical stability. These biomaterials coat either isolatly or in a combined state to enhance the colloidal stability, magnetic properties as well as prevent it cytotoxicity and surface corrosion in the biological media. These properties are essential for the particles and empowering their effectiveness in various biomedical science i.e., drug delivery Magnetic resonance imaging (MRI), hyperthermia, biosensors and gene therapy etc. Current review recapitulates the verdicts of previous research on the subject of magnetic nanoparticles. It will also explain the recent advancements of biomaterials that execute a dynamic role in various medical treatments. Our main focus is to report the particle types, design and properties as well as discussing various synthetic routes including sol gel, co-precipitation, microemulsion, green synthesis, sonochemical method and polyol synthesis etc. These methods produced particles of excellent yield with unique magnetic properties, coercivity and crystallinity and enhanced biocompatibility as compared to traditional methods used to develop MNPs.

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The objectives of this study were to examine the pattern and magnitude of deaths in road traffic crashes (RTCs) in Sindh province of Pakistan. This cross-sectional study used data obtained from government documents and content analysis of daily newspapers' reports on incidents of deaths in RTCs. Results showed that the total annual number of RTCs, fatal RTCs and deaths in RTCs were 2272 (+/-293), 1104 (+/-89) and 1321 (+/-136) respectively. On average, there were four deaths per day in RTCs. The victims were 85% male and the majority were between 15 and 49 years of age. Pedestrians, passengers, motorcyclists and drivers were most commonly the victims. Deaths in RTCs were double in rural areas compared to urban areas. The most common causes of fatal RTCs were by being hit by a vehicle, breakdown and collision of motor vehicles and speeding. The frequent involvement of the men of working age in RTCs may have serious social and economic implications; therefore, the prevention of RTCs, as far as possible, is imperative.