Various parts of sea buckthorn [Elaeagnus rhamnoides (L.) A. Nelson], particularly the berries, known also as seaberries, or Siberian pineapples, are characterized by a unique composition of bioactive compounds: phenolic compounds, vitamins (especially vitamin C), unsaturated fatty acids, and phytosterols such as beta-sitosterol. These berries, together with the juices, jams, and oils made from them, have a range of beneficial antioxidant, anti-inflammatory, and anticancer effects. This short review discusses whether sea buckthorn may represent a “golden mean” for the treatment of cancers: It has anti-proliferation properties and can induce apoptosis and stimulate the immune system, and sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping patients in general good health. Although the anticancer activity of sea buckthorn has been confirmed by many in vitro and animal in vivo studies, the treatment and prophylactic doses for humans are unknown. Therefore, greater attention should be paid to the development of well-controlled and high-quality clinical experiments in this area.

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Aim: The main objective of our studies was to determine the chemical composition and biological activities (antioxidant and anticoagulant properties) of two standardized phenolic fractions from sea buckthorn twig and leaf, and two standardized nonpolar fractions from twig and leaf in human plasma in vitro. Material & methods: Appropriately prepared extracts from sea buckthorn twigs and leaves were used. Markers of oxidative stress and hemostasis were determined in this work. Results: The reduction of plasma lipid peroxidation induced by H2O2/Fe was observed for two fractions from twig. Analysis of the effect on the coagulation properties of plasma demonstrated that the nonpolar fraction from twig and the phenolic fraction from leaf, significantly prolonged the activated partial thromboplastin time and the prothrombin time, respectively. Conclusion: Sea buckthorn twig and leaf are new promising plant materials in the prophylaxis and treatment of cardiovascular disorders.

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