Efrotomycin is a narrow spectrum antibiotic. Among the genera tested for susceptibility in vitro it is most active against isolates of Moraxella, Pasteurella, Yersinia, Haeniophilus, Streptococcus and Corynebacterium. The drug is as active by oral administration as by the subcutaneous route. Blood levels rise rapidly to high concentrations, after oral dosing, and are prolonged. Two peaks occur which may indicate biliary excretion and reabsorption. Urinary excretion is minimal. The high blood concentrations explain, in part, the in vivo

A Trichophyton mentagrophytes infection of guinea pigs induced by an occlusive procedure is described. The method of evaluation permits comparison of efficacy of antifungal agents which are not tested simultaneously. Activity was demonstrated following topical application of clotrimazole, miconazole, tolnaftate or griseofulvin and oral administration of griseofulvin. Oral ketoconazole had little effect in this dermatophyte model.

The nitroimidazole tested is structurally related to furazolidone in that it contains a 5‐nitro‐imidazole instead of 5‐nitrofuran. The nitroimidazole was much less active in vitro than furazolidone against a spectrum of pathogenic organisms. However, it is active in vivo by oral administration against bacterial infections of mice and its low acute toxicity gives better therapeutic indices than are obtained with furazolidone. Plasma concentrations rise rapidly following oral administration of the nitroimidazole. Sufficient urinary excretion occurred to give significant activity in a mouse kidney infection incited by Staphylococcus aureus in which nitrofurantoin was inactive.

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