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The effect of CaUistemon lanceolatus (Syn. C. citrinus curtis; Family: Myrtaceae) leaf oil was studied for the antinociceptive and anti-inflammatory activity in experimental animals. C. lanceolatus, 25-100 mgkg administered orally for 3 days exhibited graded dose response equivalent to 21.95%-89.90% protection in the tail flick latent test in rat. The C. lanceolatus oil (50 and 100 mgkg, given orally for 3 days) was effective in hot plate reaction time (64.05% and 112.97%, p< 0.01 and p< 0.001), analgesymeter induced mechanical pain (28.17% and 54.42%, p C 0.01 and p C 0.001) and acetic acid-induced writhing (26.68% and 51.79%, p < 0.5 and p < 0.05) in mice. The oil of C. lanceolatus potentiated the analgesic activity with pentazocine (10 mgkg, i.p.) and aspirin (25 mgkg, i.p.). In the carrageenan-induced paw edema C. lanceolatus oil (50 and 100 mglkg, given orally for 3 days) decreased paw volume significantly (26.68% and 51.79%) and dose dependent anti-inflammatory activity in 1-3 hour time interval and potentiated with nimesulide (50 mgkg, p.0.). In summary, this study demonstrates that leaf oil of C. lanceolatus has significant antinociceptive and anti-inflammatory activity.

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A patient of essential hypertension stabilized on 10 mg amlodipine once daily developed brownish black petechial non-blanching macular rash bilaterally covering the limbs below the knee and dorsum of the feet. History, general and clinical examinations and lab investigations revealed no abnormalities. Temporal association of the onset of rash with amlodipine use, inability to explain rash by natural history of hypertension, possibility of rash with amlodipine and rash resolution on dechallenge placed this reaction in Naranjo score of 6, a probable adverse reaction to amlodipine. Hence the drug was replaced by enalapril. The rash resolved completely over a period of eight weeks.