The aim of this work was to identify morpho-functional and biochemical changes in erythrocytes in students with different daily educational -training regimens after dosed physical exertion. The study involved 50 male students aged 20–22 years who study at the Faculty of Physical Education and Sports. Of these, 25 were untrained students (control group) and 25 were students studying for the highest sports qualification who were engaged in sports in which training was conducted to improve overall endurance (skiing, biathlon, long-distance running). At the end of the school year, all students were required to carry out a single session involving physical loading of maximum intensity on a veloergometer. According to the results of the questionnaire, it was found that the combination of intensive training and training processes caused a mismatch between the functional capabilities of the students’ and athletes’ biological systems and the increased volume and intensity of their psycho-physical loading, which is closely correlated with a decrease in their level of physical health. In the blood of untrained students, under the influence of dosed physical activity, reversibly altered forms of erythrocytes appeared, which accounted for 2.0% of the total number of erythrocytes. In the morphological study of student athletes, an increase in the content of reversibly and irreversibly altered erythrocytes was observed, the number of which exceeded 2.0% of the total number of erythrocytes. In individual student athletes echinocytes with small-focal microdefects of the outer membrane were observed in the peripheral blood, as well as acanthocytes and stomatocytes, which have low resistance to acid hemolysis. The mechanism of this phenomenon is a decrease in the activity of glucose-6-phosphate dehydrogenase and glutathione reductase, which leads to a deficiency of reduced glutathione in erythrocytes. Such cells under the influence of oxidizing agents quickly undergo lysis, which is manifested by a violation of their structural integrity. This can lead to the development of “anemia of loading”, which is manifested by a decrease in the concentration of hemoglobin and the number of erythrocytes with their morphometric recalibration due to the appearance of macro-microcytic forms. The presence of such changes can adversely affect both the athletic performance and the state of health of students. This requires appropriate correction of the training process, as well as the development and timely application of adequate measures aimed at eliminating the development of the pathological process and eliminating possible undesirable consequences.

Actuality. Increasing number of macrocycles during athletes’ training focused on the achievement of high sports results leads to lower adaptive potential and as a result to the pre and pathological conditions, including – respiratory tract dysfunction. The aim – to analyze prevalence and reasons of respiratory tract dysfunction in athletes of high qualification. Results. The analysis of modern scientific data indicates high prevalence of asthma among professional sportsmen, skiers – 14–55 %, swimmers – 13–44 %, long-distance runners – 15–24 %. Professional sportsmen have got induced by physical loading laryngeal obstruction that is the main reason of larynx obstruction. The prevalence of this pathology among healthy population is ~ 5 % while among athletes – from 35 % to 70 %. Symptoms that indicate the infection of upper respiratory tract are between 30 to 40 % of the complaints of professional sportsmen in health facilities, especially among runners, cyclists, skiers, swimmers, rowers, and – tennis players and gymnasts. Currently, many experts hold to the hypothesis of «non infectious» nature of symptoms of URTI, likely of allergic nature. Risk factors, mechanisms of respiratory tract dysfunction in sportsmen were analyzed. Conclusions. The prevalence of respiratory tract dysfunction (asthma, induced by physical loading laryngeal obstruction, chronic cough, respiratory infections) among qualified athletes is much bigger than among the normal population. Determining risk factors are atopy, ventilatory needs of the kind of sport and training environment.

Balance dysfunction in elderly patients with Parkinson’s disease (PD) is a high-risk fall precaution, along with sarcopenia and senile asthenia, which leads to traumas, including fractures of the proximal humerus fractures (PHF). The objective of the study was to determine the effectiveness of a functional training as part of a physical therapy program on balance, upper limb (UL) function, daily living activities, and quality of life in elderly patients with PD and frailty, following proximal humerus fractures. We examined 33 elderly patients with PD and frailty in the recovery period after PHF. The control group included individuals who underwent rehabilitation according to the general principles of kinesitherapy. The treatment group consisted of patients engaged in a program of physical therapy directed at improving balance, function of the upper UL, motor stereotype, and activities of daily living. The effectiveness of the program was evaluated using the Short Physical Performance Battery (SPPB), Berg Balance Scale (BBS), Disability of the Arm, Shoulder and Hand Outcome Measure (DASH), Wrist Dynamometry, Falls efficacy Scale International (FES-I), Barthel Activities of daily living (ADL) Index, Lawton Instrumental activities of daily living (IADL) Scale, PD Questionnaire-39 (PDQ-39). According to all studied indicators, the patients of both groups showed a statistically and significantly better result compared to the initial data (p<0.05), but the treatment group showed better outcomes compared with the control group (p<0.05).