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Currently, there is an increasing interest towards -glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B-and C-type viral hepatitis. Cinnamic acid derivatives have been shown to be potentially valuable as a new group of -glucosidase inhibitors. Therefore, herein, the -glucosidase inhibitory activity of trans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro. Results revealed that the tested hydroxycinnamoyl amides (1-16) inhibited a-glucosidase with IC 50 s ranging between 0.76 and 355.1 g/ml. Compounds 1, 2, 5, 6, 9, 14, and 15 showed significant inhibition of yeast -glucosidase, being even more potent ones than the used positive inhibitor acarbose (IC 50 = 2.50 ± 0.21 g/ml).

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