A relatively simple dance-based exercise can support lower-body functioning in previously sedentary, frail older adults.

Nowadays NSAIDs are the most frequently used groups of drugs, especially because of their availability. Their consumption is high among older people, who are much more sensitive to the side effects, and who are often also taking other drugs which can interact with them. Moreover, the majority of the older population is suffering from hypertension. This could well explain the commonly encountered experience of drug interaction between NSAIDs and antihypertensive drugs, which is very common in clinical practice. The severity of this drug interaction is classified as class C, with a recommendation to monitor therapy. However, even a minor long-term increase in blood pressure can significantly increase the risk of cardiovascular mortality, while mortality rates can possibly be reduced by sufficiently effective treatment of hypertension. Therefore, in clinical practice, this type of interaction should not be overlooked as a major cause of failure of hypertension treatment in older patients, as well in many cases in general. The present article focusses on the mechanism and the degree of influence on the blood pressure of particular types of antihypertensive agents used in combination with NSAID. Not all groups of antihypertensive drugs are affected to the same degree; some are more affected, and others, such as calcium channel blockers, are not affected at all. Similarly, not every NSAID increases blood pressure. Many studies, some of which are analyzed in this article, present evidence of the degree of the influence NSAIDs have on blood pressure (Adv Clin Exp Med 2014, 23, 6, 993-1000). Hypertension is well known as one of the most common cardiovascular diseases. Approximately 690 m people around the world suffer from hypertension. It is one of the major risk factors causing arteriosclerosis, including atherogenic coronary artery disease in the form of ischemic heart disease [1]. Hypertension affects the majority of people over 65 years of age, occurring in up to 60% of this population [2]. In most cases, it accounts for subsequent organ damage or many other manifestations of cardiovascular diseases [2,3]. Adequate treatment of hypertension is important especially in older populations, as has been confirmed by the HYVET study [4]. Moreover, older populations often experience pain, both chronic and acute. The use of different analgesics therefore becomes a regular part of their lives. It should therefore be borne in mind that the treatment of hypertension may be significantly influenced by the concomitant use of other therapeutic classes.The authors of this article focused on clarifying the mechanisms of the influence on blood

Aims:We are currently witnessing changes in views on the evaluation of serum proteins. A decrease may signal not only malnutrition. It may also be an indicator of simultaneously occurring infl ammatory disease. Prealbumin, due to its short half-life, is a suitable indicator of changes in protein-energy balance, but its levels show, as with other serum proteins, a decrease in the case of infl ammation too. The present study aimed to determine the prealbumin values of hospitalized geriatric patients and how they are aff ected by infl ammatory disease.Methods: In 101 patients aged over 80 years, the relationships were compared between prealbumin and C-reactive protein in the whole group and then in the subgroups with normal and increased C-reactive protein.Results: In 67.33 % of hospitalized geriatric patients prealbumin was below the limit of the norm. A statistically highly signifi cant dependence (p < 0.001) was demonstrated between a decrease in prealbumin and an increase in Creactive protein in the whole group. In the subgroup with normal C-reactive protein, no statistically signifi cant decrease in prealbumin was demonstrated, whereas in the subgroup with increased C-reactive protein a signifi cant decrease in prealbumin (p < 0.001 for the whole group, p < 0.01 men, p < 0.05 women) was found.Conclusions: The study demonstrated subnormal mean initial values of prealbumin and a highly statistically significant negative correlation between a decrease in prealbumin and an increase in C-reactive protein in the whole group. We confi rm that in infl ammation there is a statistically signifi cant decrease in serum concentration of prealbumin.

Decreased levels of TGF β in Alzheimer's disease may result in impairment of cerebral circulation reflected in the increased endoglin levels. These findings may indicate involvement of the immune system in Alzheimer's disease pathogenesis.