There are about 30 different types of blueberries. In Bulgaria, there are 4 species of genus Vaccinium - red (vitis-idaea), black (myrtillus), blue (uliginosum) and Caucasian (arctostaphylos). Bilberries are a source of carotene, vitamin B1, vitamin B2, potassium, sodium, calcium, magnesium, phosphorus, iron, vitamin D, manganese, soluble and insoluble fibres like pectin. Blueberries contain significant amounts of anthocyanidins, antioxidants and ellagic acid. The main wealth of blueberries are the antioxidants that bind free radicals and thus prevent malignant tumors. This is why blueberry is an excellent remedy for oncology. Objective of study was to investigate the content of total polyphenols, antioxidant activity and total anthocyanins of bilberry depending on altitude. Systematic approach and critical analysis of the available scientific periodicals and DPPH method for determining the antioxidant activity (radical trapping activity). It has been established a direct relationship between altitude and antioxidant activity. In the range of 900 to 1450 m the relationship between altitude and total anthocyanins is inversely proportional. After 1500 m, the dependency becomes proportional. There is no correlation between pH, total polyphenols and titratable acidity.

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Many beverages such as soft drinks, coffee and tea contain the mild stimulant caffeine (C 8 H 10 N 4 O 2). The caffeine content varies widely from about 100 µg/mL (100 ppm) in sodas to over 1000 µg/mL in certain types of coffee. For this reason the caffeine and the content in they need to be analyzed. A rapid and selective high-performance liquid chromatographic (HPLC) method is developed for the separation and determination of caffeine.

Herbal medicines have evolved through their traditional use in a specific or cultural context. The pharmacological effects of herbal medicines are not due to their “natural” origin, but to the complex character of biologically active substances. Pediatricians have begun to integrate the use of complementary / alternative medical therapies with conventional health care. The first aim of the study was to make an analysis of over-the-counter (OTC) drugs (OTCDs) with a plant component. The secondary aim was to investigate OTCDs in terms of composition and nosology for use by the pediatric population in Bulgaria. Registered OTC drugs with a herbal component for children are prescribed for the treatment of colds, pain, gastrointestinal diseases, mild sleep disorders, neurovegetative dystonias and kinetosis, urinary tract inflammation, liver disease, and are also applied topically to inflammation, trauma, urticaria and scars.