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Screen identifies genes that affect tumor behavior in a wide variety of ways A functionally validated network of invasionsuppressor genes was generated Loss of cohesin complex function can promote individual or collective cell invasionThe fly pupal notum is an excellent in vivo system to study tumor progression

Cells are permanently exposed to a multitude of different kinds of signals: however, how cells respond to simultaneous extracellular signals within a complex in vivo environment is poorly understood. Here, we studied the role of the mechanosensitive ion channel Piezo1 on the migration of the neural crest, a multipotent embryonic cell population. We identify that Piezo1 is required for the migration of Xenopus cephalic neural crest. We show that loss of Piezo1 promotes focal adhesion turnover and cytoskeletal dynamics by controlling Rac1 activity, leading to increased speed of migration. Moreover, overactivation of Rac1, due to Piezo1 inhibition, counteracts cell migration inhibitory signals by Semaphorin 3A and Semaphorin 3F, generating aberrant neural crest invasion in vivo. Thus, we find that, for directional migration in vivo, neural crest cells require a tight regulation of Rac1, by semaphorins and Piezo1. We reveal here that a balance between a myriad of signals through Rac1 dictates cell migration in vivo, a mechanism that is likely to be conserved in other cell migration processes.

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PurposeComprehensive poverty measures are increasingly gaining importance since people's deprivations and needs cover aspects beyond income. For this reason, the goal of this article is to propose a methodology to measure poverty that includes objective social deprivation, income deprivation and subjective social deprivation, using Mexico City and its municipalities as the study context. In order to show areas of intervention of public policies, the authors discuss the dimensions and indicators used in the multidimensional measurement.Design/methodology/approachUsing the Social Welfare Survey (N = 2,871), the authors measure poverty with the Alkire-Foster methodology. The applied concept of poverty includes objective and subjective deprivations, and income.FindingsThe interaction between objective and subjective deprivations shows that income, social cohesion, built environment and public insecurity are important areas for the redesigning of public policies.Originality/valueThe employed method to measure poverty emphasizes the relevance of including subjective deprivations in interaction with objective deprivations and income. It evidences the need for the implementation or strengthening of public policies.