Maternally derived thyroid hormones (THs) deposited in yolk promote fish embryogenesis and survival, and understanding early regulatory mechanisms could lead to improved seedstock production. We have tested the hypothesis that some thyroid actions may be mediated by insulin‐like growth factor I (IGF‐1), another promoter of embryo development. Differentiation and performance were assessed in embryos treated with THs in the presence or absence of an IGF‐1 receptor blocking peptide. Treatment with the TH triiodothyronine (T3) promoted IGF‐1 gene expression at days 1 and 5, and advanced swim bladder and eye development, but blocking the IGF‐1 receptor eliminated the swim bladder and eye effects. Growth and survival at 1 week of age were impaired by the IGF‐1 receptor blocking peptide alone, but concurrent treatment with T3 partially restored these indices. Our results confirm interaction of T3 and IGF‐1 regulatory signalling in zebrafish embryogenesis and transduction by IGF‐1 of thyroid‐driven swim bladder and eye maturation.

Bangladesh is considered as one of the most suitable riverine country endowed with the rich inland and marine fisheries resources with enormous aquaculture potential. The suitable geographical location of Bangladesh along with its huge number of aquatic species offer excellent opportunities for the effective utilization and management of fisheries resources. Fisheries sector in Bangladesh represents as one of the most productive and dynamic sectors in the country. The country’s fisheries sector plays a significant role in food security, employment, and foreign exchange earnings in the economy. The sector contributes 3.65% to the national GDP and 23.81% to the total agricultural GDP. Fish and fishery products are the country's second largest export commodity contributing 1.97 percent of its exchange earnings in 2015–2016. From the year 2000 to 2016, aquaculture production increased from 712,640 to 2,060,408 mt, which was much higher than wild capture production of 1.023 million mt in 2016. There has also been a recent increase in the value of fishery exports, with more than US $34.08 billion in 2010 rising to more than US $46.60 billion in 2015. However, fisheries production is well below production targets despite the large gains seen in the aquaculture sector. However, the fisheries sector in the 21st century is facing the challenges of food security for the increasing population, habitat degradation, urbanization, and industrial development. Development of responsible fisheries management and optimal use of water bodies can address those challenges. Since fishery is a productive growth sector in Bangladesh, it has high potential to contribute in the socioeconomic development of the country. In this paper, we also make an attempt to examine the current legal status of Bangladesh fisheries and constraints in the implementation of fisheries laws. It is identified that twelve fisheries regulations are executed for the regulation and management of the fisheries resources in Bangladesh. Among these laws, a few are historically important for the regulating and managing of fisheries. These laws are implemented with some amendments for the development of legal mechanisms for fisheries development of Bangladesh. The implementations of these laws often met limited success due to a number of shortcomings in the legislations. The constraints in the implementation are the lack of clear policy guidelines and strategy; inadequacy of existing regulatory framework, non-enforcement of legislation and jurisdictional conflicts, the absence of regular law review and updating mechanism and formulation of by-laws, rules, orders etc. However, in recent years, Bangladesh Government has taken some initiatives towards the conservation and management of fish stocks (e.g., hilsa fishery), both to optimize total production and ensure fisher’s livelihoods. Furthermore, a comprehensive legal framework is required for sustainable management of fisheries resources in Bangladesh.

Purpose: To evaluate the efficacy of a biosimilar ranibizumab (Razumab) on outcomes of retinopathy of prematurity (ROP) for the first time. Methods: This retrospective study included infants presenting with stage 3+ ROP either in zone 1 or zone 2 posterior or aggressive posterior ROP (APROP). All eligible infants received intravitreal razumab (0.25 mg/0.025 ml) monotherapy. Follow-up was continued monthly till complete retinal vascularization was achieved while retreatment with razumab was given when recurrent neovascularization was noted. In case of no recurrence but incomplete vascularization, laser photocoagulation was done to the residual avascular retina. Results: We included 118 eyes of 59 infants with a median gestational age of 30 weeks and median birth weight of 1250 grams. At presentation, APROP was found in 28 eyes (24%) of 14 babies while stage 3 disease was seen in zone 1 in another 28 eyes (24%) and the remaining 62 eyes (52%) had stage 3 ROP in zone 2 posterior region. Complete resolution of ROP along with complete vascularization was seen in 22 eyes (19%) at a median of 55 days (IQR = 31–56 days) and 42 eyes (35%) showed a recurrent neovascularization at a median of 51 days post razumab (IQR = 42–55 days). The cumulative incidence of recurrence of neovascularization (21%, 95% CI = 14%–29%) peaked at seven weeks and was significantly higher in eyes with APROP (43%, 95% CI = 27%–63%) compared to eyes without APROP (13.4%, 95%CI, 8%-22%) ( P < 0.001). Conclusion: Razumab appears to be safe and effective in treating ROP, with about a third requiring reinjection at seven weeks after the first dose.

The present study investigates the geo-morphological features, hydro-biological profiles and resource characteristics of some selected wetlands in Brahmanbaria district, Bangladesh. Two categories of wetland have been classified on the basis of area such as the small category (40-100 ha), which belongs to 11 wetlands and the large category (100-200 ha) to nine wetlands. The mean depth of all the surveyed wetland does not exceed 3.29 ± 0.83 m. The mean value of organic matter was measured as 7.5 ± 6.34%. The maximum organic matter was recorded at Gagotia beel (24.60%) and the minimum organic matter was recorded at Kajolia beel (2.06%). The mean value of organic carbon was measured as 3.93 ± 3.33%. The highest amount of organic carbon was found at Gagotia beel (12.95%) while the lowest amount of organic carbon was observed at kajolia beel (1.08%). Soil texture indicates the percentage composition of sand, silt and clay in sediment. The average concentration of sand, silt and clay was recorded to be 53.31 ± 15.32, 17.61 ± 9.56 and 29.08 ± 12.87%, respectively. Among the 20 selected wetlands examined, 13 were found to be perennial wetlands where water is available throughout the year. There was significant difference among different wetlands in terms of organic carbon, organic matter, sand, silt and clay (P < 0.05) as analyzed by One Way Analysis of Variance (SPSS v.22). The sampling stations were presented as a map created by GIS (ArcMap v.10.1). This qualitative and quantitative assessment will not only provide new information about the geo-morphological and hydro-biological insights into the wetland but also will facilitate the development, management, and conservation of aquatic biodiversity in a significant and worthwhile manner.