Conclusions-HPV infection was found to be a multicentric genital andlor anorectal event both in women and men. The oral presence of HPV DNA was detected only once in one of the participants. In women persistent HPV infection was more common than in men. Independent predictors for presence of HPV DNA in women were diagnosis of condylomata acuminata, reporting genital dermatologic abnormalties and age. Incidence of HPV infection in women turned out to be 47*1 infections per 100 person-years and for men 50.5 per 100 person-years. (Genitourin Med 1994;70:240-246) Introduction Over the last decade knowledge about the epidemiology of human papillomavirus (HPV) infection has been expanding, but many controversial questions remain to be answered. Which anatomical sites are harbouring the latent or occult papillomavirus infections both in men and women?' What is the natural history of HPV infection and what is the subsequent risk of invasive cancer?2 To answer some of these questions we performed a longitudinal study among heterosexual men and women with multiple sexual partners to assess the prevalence, incidence and potential risk factors of genital HPV infections. In addition, we wanted to investigate the existence of latent and subclinical infection and to identify the niches of HPV.

Risk perception and behavior: pessimism, realism, and optimism about AIDS-related health behavior van der Velde, F.; Hooykaas, C.; van der Pligt, J.

Perceiving AIDS-related risks: Accuracy as a function of differences in actual risk van der Velde, F.W.; van der Pligt, J.; Hooijkaas, C.

Conditional versus unconditional risk estimates in models of AIDS-related risk behaviour van der Velde, F.W.; van der Pligt, J.; Hooykaas, C.

A prospective study of 65 men and 111 women with multiple heterosexual partners was designed to assess the prevalence and potential risk factors of genital human papillomavirus (HPV) infections. In addition, the HPV reservoir in genital, rectal, and oral mucosa was examined. The specimens for the detection of HPV DNA were taken from different sites such as the urethra and coronal sulcus (men), cervix and labia minora (women), anus, rectum, tongue, and buccal mucosa (both men and women). Women underwent speculum examination and colposcopic evaluation of the anogenital region, and a smear for routine cytological classification was also taken. In men, the anogenital region was examined clinically and colposcopically. The polymerase chain reaction (PCR) was used for the detection of HPV types 6/11, 16, 18, and 33. A high prevalence of HPV infection at one or more sites was detected, in 32% of the male and in 23% of the female participants. Seventeen percent of the male distal urethral specimens were positive for HPV DNA. From the female cervical specimens 14% were found positive. Ten proctal specimens (five men and five women) were positive for HPV DNA without any discernible lesion. The persons from whom these samples were taken denied anal insertive intercourse. No oral manifestation of HPV infection was detected. In both men and women a difference between HPV DNA-positive and -negative persons was not found in relation to known risk factors associated HPV infection.(ABSTRACT TRUNCATED AT 250 WORDS)