The development of chronic pain is a complex mechanism that is still not fully understood. Multiple somatic and visceral afferent pain signals, when experienced over time, cause a strengthening of certain neural circuitry through peripheral and central sensitization, resulting in the physical and emotional perceptual chronic pain experience. The mind-altering qualities of psychedelics have been attributed, through serotonin 2A (5-HT2A) receptor agonism, to ‘reset’ areas of functional connectivity (FC) in the brain that play prominent roles in many central neuropathic states. Psychedelic substances have a generally favorable safety profile, especially when compared with opioid analgesics. Clinical evidence to date for their use for chronic pain is limited; however, several studies and reports over the past 50 years have shown potential analgesic benefit in cancer pain, phantom limb pain and cluster headache. While the mechanisms by which the classic psychedelics may provide analgesia are not clear, several possibilities exist given the similarity between 5-HT2A activation pathways of psychedelics and the nociceptive modulation pathways in humans. Additionally, the alterations in FC seen with psychedelic use suggest a way that these agents could help reverse the changes in neural connections seen in chronic pain states. Given the current state of the opioid epidemic and limited efficacy of non-opioid analgesics, it is time to consider further research on psychedelics as analgesics in order to improve the lives of patients with chronic pain conditions.

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The eighth season of the Joint Expedition of the British Museum and of the Museum of the University of Pennsylvania started at Ur on 1st November 1929, and ended on 19th March 1930. The staff consisted of my wife, who as usual was responsible for the type-drawings of objects, the planning of the cemetery, and for a share in the field-work; Mr. M. E. L. Mallowan, general archaeological assistant; the Rev.E. Burrows, S.J., epigraphist; and Mr. A. S. Whitburn, architect. Hamoudi was, as always, head foreman, with his sons, Yahia, Ibrahim, and Alawi acting under him; owing to the fact that work was always going on in at least two spots fairly far apart, greater responsibility than usual was thrown on the younger foremen, who answered admirably to the demands on them; Yahia combined this work with that of staff photographer. The number of men employed varied slightly at different times, but was always over 200 and for most of the season kept at about 240, anumber well in excess of the average of past seasons; the amount of work done wascorrespondingly great. I have to thank the Royal Air Force in Iraq for help of many sorts and not least for an air photograph of the site (pl. XXVIII) taken at the close of the season and of much value for purposes of comparison with earlier photographs; Lt.-Colonel Tainsh, Director of the Iraq Railways, for facilities enabling me to undertake a short experimental dig at Meraijib, a prehistoric site some ten miles south of Ur; and the Director of Antiquities, Iraq, for his help in this Meraijib work and to the Expedition in general. I must also acknowledge my indebtedness to the staff of the British Museum Laboratory, where the work of restoring and cleaning was as usual carried out, and in particular to Mr. E. C. Padgham for his success with the silver objects; Mr. Evan Watkin of the Department of Egyptian Antiquities undertook the mending of the stone vases, and for the mending of the pottery the services of Mrs. F. W. Bard were secured.

The Iraqi Government is proposing to supersede the Antiquities Law drawn up eleven years ago, and approved by the League of Nations, by one which will admittedly be far more onerous to the foreign excavator working in Iraq. As a prelude to the introduction of the bill before the Iraqi Parliament there has been a regular campaign of propaganda intended to show that under the existing law Iraq has been robbed, by concessions made to foreign missions, of the treasures which were legally and morally hers, and that Iraq never has had fair treatment and will not have it so long as the division of the objects from excavations is conducted by a foreign Director of Antiquities. To what lengths this campaign has been carried may be illustrated by the following: in March 1934 Abdal Rizaq Effendi, the Curator of the Baghdad Museum, personally repeated to me the statement, published in the local press, that the normal share accruing to the Baghdad Museum from the division of antiquities with a foreign mission, as conducted by the Director, was no more than one half of one per cent. of the objects catalogued.