Isoniazid induced hepatotoxicity is a major concern in patients taking anti tuberculosis treatment and prophylaxis. It can result in elevated serum liver enzymes and hepatic failure. The aim of the study was to evaluate the phytochemicals and ameliorative effects of aqueous extracts of Brysocarpus coccineus on serum liver enzymes in isoniazid (INH) induced hepatotoxicity in adult male Wistar rats. Thirty six (36) adult male Wistar rats were divided into six groups of six rats each and were treated orally for 30 days as follows: Group I: 1 ml/kg of distilled water; group II: Isoniazid (27 mg/kg); group III: Isoniazid (27 mg/kg) + Livolin forte (20 mg/kg); group IV: Isoniazid (27 mg/kg) + B. coccineus (200 mg/kg); group V: Isoniazid (27 mg/kg) + B. coccineus (400 mg/kg); group VI: Isoniazid (27 mg/kg) + B. coccineus (800 mg/kg).At the end of the experiments, the Wistar rats were sacrificed and sera obtained for liver enzymes assay, whereas the liver tissue was also harvested and used for histological studies. Tanins, saponins, alkaloids and flavonoids were quantitatively present at 2.29%, 18.05%, 23.24% and 18.99%, respectively. There was an increase in the serum AST and ALT in the isoniazid treated group, which was reversed by livolin forte and the aqueous extracts at a dose of 200 mg/kg, however the extracts increased the serum levels of AST and ALT at higher doses, which was however not significant (p > 0.05) when compared to the controls. There was evidence of a reduction in hepatocytes

Aims: The study was aimed at comparative evaluation of body weight changes and the serum growth hormone level in female lactating Wistar rats treated with normal saline, metoclopramide olanzapine and risperidone. Study Design: A total of twenty (20) Female Wistar rats weighing between 140-180 g were used for the study. The study was an experimental study carried out on lactating rats. Treatment started three days after parturition. Two atypical antipsychotic drugs were administered orally and their effects compared to that of a normal control group and a positive control.

Aims: This study was designed to evaluate the phytochemical constituents, lipid peroxidation and superoxide dismutase activity of methanol leaf extract of Securidaca longepedunculata (polygalaceae) (MLESL).

Aim:Increase in blood glucose level has been associated with beta cells destruction which is enhanced by lipid peroxidation and hepatocellular damage. The present study was designed to investigate the effect of oral administration of theophylline on Liver enzymes (ALT, AST and ALP) and Liver histology in alloxan-induced diabetic male wistar rats. Study Design: This is an experimental study. Thirty healthy male wistar rats weighing between 160-180 g were grouped into five of six animals each (n=6) following the induction hyperglycaemia using Original Research Article

Aim: Lipids are referred to as one of the primary targets of reactive oxygen species (ROS). The main sources of oxidative stress in diabetes mellitus comprise various enzymatic pathways, nonenzymatic pathways and mitochondrial pathways. This study was designed to evaluate the effect of theophylline and treatment on lipid peroxidation (serum malondialdehyde concentration) and some