Background The beneficial effect of intravitreal ranibizumab in the treatment of neovascular age-related macula degeneration (nAMD) is well known. Outcome data for eyes presenting with visual acuity better than 6/12 is limited. Aims To assess the effect of baseline vision on outcome in ranibizumab-treated nAMD eyes, including a subgroup with baseline vision Z6/12 (o0.30 logmar). Design Prospective, consecutive and interventional case series. Methods A consecutive cohort of patients treated with intravitreal ranibizumab for nAMD with 52-week follow-up were studied. Patients who had received previous treatment for nAMD were excluded. Eyes were stratified according to baseline logmar visual acuity into four groups: o0.30 (46/12), 0.30-0.59 (6/12-6/24), 0.60-0.99 (6/24-6/60) and 1.00-1.20 (6/60-6/96). Intravitreal ranibizumab (0.5 mg in 0.05 ml) was administered in three loading monthly doses followed by PRN dosing according to optical coherence tomography (OCT) findings. Results A total of 615 eyes were studied including 88 eyes with baseline vision o0.30. The mean change in logmar letters at 52 weeks was þ 5.5 (entire study group), À0.5 (o0.30 subgroup), þ 2.2 (0.30-0.59 subgroup), þ 6.5 (0.60-0.99 subgroup) and þ 15.3 (1.00-1.20 subgroup). In the o0.30 subgroup, 60 of 88 eyes (68%) had best-corrected visual acuity (BCVA) equal to or better than baseline and 82 of 88 eyes (93%) lost o15 letters at 52 weeks.

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Purpose: The ''traffic light'' color designation of differential light sensitivity used in a number of microperimeters does not encompass the conventional Total and Pattern Deviation probability analyses adopted by standard automated perimetry. We determined whether the color designation is indicative of abnormality as represented by the ''gold standard'' Pattern Deviation probability analysis. Methods: Total and Pattern Deviation probability levels, using two different methods, were derived at each of 40 stimulus locations, within 78 eccentricity, from 66 ocular healthy individuals (66 eyes) who had undergone microperimetry with the Macular Integrity Assessment microperimeter. The probability levels were applied to the corresponding fields from each of 45 individuals (45 eyes) with age-related macular degeneration (AMD) and evaluated in relation to the color designation. Results: Sensitivities designated in orange encompassed the entire range of Pattern Deviation probability levels (from normal to P 1%). Those designated in green were mostly normal; those in red/black generally corresponded to the 1% probability level. Conclusions: The green and the red/black designations are generally indicative of normal and abnormal probability values, respectively. The orange designation encompassed all probability outcomes and should not be relied upon for visual field interpretation. The evidence base indicates replacement of the color designation of sensitivity in AMD by Total Deviation and Pattern Deviation analyses. Translational Relevance: The use of Total and Pattern Deviation probability analyses is not universal in all microperimeters, and the derivation of these values indicates that color coding will lead to errors in evaluating visual field loss.

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