This study aims to analyse students’ self-efficacy in chemistry learning. Descriptive quantitative method was used in this research. The research respondent was 77 senior high school student in Yogyakarta Indonesia. Data collection techniques was survey. Instruments used for collecting data was questionnaire sheet. The data analysis technique used was V’Aiken equation to analyse experts judgement in validation process and likert scale to analyse self-efficacy data. The results of this study were 1) 53% of student had higher criteria of self-efficacy and 47% had lower of it, 2) the factors affecting students’ self-efficacy were motivation, personal experience, phsycology, emotional, and social environment. The more factors owned by student, the more students’ self-efficacy rose otherwise their self-efficacy will decrease.

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