The study was approved by the Ethics Committee for the Analysis of Research Projects of the HCFMUSP (approval number: 34115720.5.0000.0068). Study design and locationThis cohort study is in progress, and will evaluate 400 patients who were admitted to referral hospitals for SARS-CoV-2 infection. The study will conduct a 1-year follow-up among these patients at four evaluation time points: 1, 4, 6, and 12 months after hospital discharge.

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Background and Objectives Hospitalization by Covid‐19 can cause persistent functional consequences after hospital discharge due to direct and indirect effects of SARS‐COV‐2 in several organs and systems of the body added to post‐intensive care syndrome and prolonged bed rest. These impacts can lead to dependency in activities of daily living, mainly in older people due to aging process and functional decline. This study aimed to compare the effects of hospitalization by Covid‐19 on functional capacity of adults and older people and to identify its associated factors. Methods Cross‐sectional observational study of 159 survivors of hospitalization by Covid‐19 after 1 month from discharge at Hospital das Clínicas of the University of São Paulo, divided into groups: adults (aged < 60 years) and older people (aged ≥ 60 years). Those who did not accept to participate, without availability or without ability to understand the questionnaires were excluded. Functional capacity was assessed by the Barthel Index and patients were classified according to their scores. Data analysis was performed in JASP Statistics program and the sample was compared between the age groups. Wilcoxon test was applied to compare before and after periods, Mann–Whitney test was used for between groups comparison. We adopted alpha = 0.05. Results The total Barthel Index median score was lower 1 month after hospital discharge than in the pre‐Covid‐19 period. Older people had worse functional status than adults before and also showed greater impairment after hospital discharge. Both groups showed lower Barthel Index classification than before, and older people presented more functional dependence than adults in both periods. Age, sarcopenia and frailty were associated factors. Discussion Hospitalization by Covid‐19 impacts functional capacity after 1 month from discharge, especially in older people. Age, sarcopenia and frailty are associated factors. These results suggest need for care and rehabilitation of Covid‐19 survivors.

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Background: Cognitive damage is observed in those hospitalized by COVID-19, which may be associated with hypoxia and sedation, but it is not established whether there is an association with postural control. Objective: To verify the correlation between cognition and postural control of individuals hospitalized by COVID-19. Design and setting: Prospective cohort study at a referral hospital for the treatment of severe cases by COVID-19. Method: The primary end point was cognition (10 CS) and the secondary end points with postural control (Brief Best Test), mobility (Time Up and Go - TUG) and muscular endurance and strength (time to sit and stand 5 times and 1 minute [min]). Data analysis was performed using the JASP software and a significance level of p<0.05 was adopted. For descriptive analysis, mean, standard deviation and frequency were used. Pearson’s coefficient test was used to analyze possible correlation between variables. Results: As preliminary results, 91 patients with average age (59.29 ± 11.37) years, 54.94% female and 45.05% male were evaluated. There was a weak negative correlation between 10CS and Brief (r = -0.270; p = 0.013), a strong positive correlation between 10CS and sitting and standing time 5 times (r = 0.404; p<0.001) and a negative correlation between 10CS and sitting test and raise 1 me. (r = -0.342; p = 0.002). There was no association between 10CS and TUG over 12.6 seconds. Conclusion: In patients who presented cognitive deficit after hospitalization due to COVID-19, an association with deficit in postural control, resistance and muscle strength was observed.