The Paraiba do Sul River delta, a South America east coast system, presents deposits recording complex sedimentary dynamics in the deltaic plain during the Little Ice Age (LIA). The use of optically stimulated luminescence (OSL) dating, sediment grain-size characterization, and morpho-chronological analysis showed that from ∼450 to 100years (LIA period), both in lower to upper deltaic plain, remodeling occurred in conjunction with the coastline regression. The freshwater and sediment influx increases due to the moisture enhancements during the LIA resulted in the intensification of the fluvial dynamic, channel downcutting on the marine terrace, and sedimentary environments remodeling. Further, the base-level changes occasioned by the coastline regression strengthen the geomorphological dynamics associated with the recent changes in the Paraiba do Sul delta. Currently, the coastal erosion problem found in the area seems to reflect the coupling between climate dynamic (rainfall rates decrease) and multiple-scale anthropic intervention. Results show a high sensitivity of humid tropical deltaic systems to short-time climate events, further contribute to broadening discussions on the complexity of this delta system’s morphosedimentary evolution during the Late Holocene.

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Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis. We report herein all cases of ALEP described in literature, adding the case of a 35-year-old woman admitted to our hospital with outbreak of erythematous pustules on her face, neck, and chest after amoxicillin–clavulanic acid treatment.

Clinical management of alopecia represents one of the major issues in dermatology. Scalp biopsies are not easily accepted because of the high bleeding and sensitive anatomical area. Trichoscopy is routinely used for diagnosis of alopecia, but in several cases lack to provide sufficient information on the status of the disease. Recently, reflectance confocal microscopy demonstrated its usefulness for the evaluation of several inflammatory skin condition and preliminary reports about alopecia have been proposed in the literature. The aim was to identify the confocal features characterizing scarring and non-scarring alopecia. Reflectance confocal microscopy from 86 patients affected by scarring (28 lichen planopilaris and 9 lupus erythematosus) and non-scarring alopecia (30 androgenic alopecia and 19 alopecia areata), were retrospectively, blinded evaluated. Good concordance between different readers on the confocal criteria has been assessed. Statistical significant features, specific for scarring alopecia and non-scarring alopecia have been identified. In this study, data on reflectance confocal microscopy features useful for the differential diagnosis between scarring and non-scarring alopecia have been identified. Further studies focusing on the use of this non-invasive technique in the therapeutic follow-up and distinction of sub-entities of alopecia are still required.