Given the uncertain outlook caused by COVID-19, it is important to carry out a review of the conditions in which the collective enterprises are influenced by the four helix model, specifically those dedicated to the sector most affected by the pandemic, tourism, for which raises the question: What have been the results of the four helix model in the social tourism entrepreneurships (STE) of Jalisco and Nayarit? In addition to: the participation of the actors of the four helix model has contributed to face the repercussions of COVID-19? The objective is to identify stakeholder input from the core elements of the four helix model and sustainability to the STEs during COVID-19. The methodology used was qualitative and involved the comparison of information from 12 key stakeholders from the government, social, academic and private sectors through Atlas.ti-8. Some results indicate that from the perception of the participants interviewed, the COVID-19 crisis has promoted innovation, support, and incentives among the four helixes, in which the STEs have benefited. As conclusions, the four helix model is functional to face the adversities of COVID-19 as long as there is planning within the entrepreneurships and the link with said model helix participants.