Introduction:The Zika virus has the ability to tropism in neuronal cells of fetuses, congenitally causing neurological disorders. Objective: To discuss the relationship between congenital Zika virus infection and the onset of congenital neurological abnormalities in newborns, including their neurological manifestations, and their impact on quality of life. Methods: Bibliographic review developed from October to November 2022, with searches in the PubMed and LILACS databases, 15 articles being selected after applying inclusion criteria. Discussion: Infections in the first trimester of pregnancy are those that result in serious malformations, which reinforces the importance of adequate prenatal care. The diagnosis of infection during the gestational period consists of serological and ultrasonographic examinations. The main manifestation observed intrauterine and after birth was microcephaly, which is characterized by the interruption of brain growth, with little cortical differentiation. However, changes in sensory organs can also occur. Final considerations: The studies demonstrate advances in the screening of such changes through possible radiological and laboratory changes during prenatal care, and also through postnatal neuroimaging tests.

Goal: Dissertation about the effective indications for massive transfusion in patients with severe trauma. Method: Literature review prepared between October and November 2022, through a search in the Scielo and Pubmed databases with the descriptors "massive transfusion", "blood Component transfusion", "protocol" and "indications". 5353 articles were found and, after the inclusion and exclusion criteria, 13 studies were selected. Review: Hemorrhage is a preeminent cause of possibly preventable mortality in cases of trauma and in many cases requires massive transfusions (MT). Thus, in clinical practice it is mainly based on guidelines that determine different TM protocols (MTP). After the appreciation of an abundance of clinical parameters of the patient, one can opt for the massive transfusion that must be performed in a period of 24 hours. Conclusion: The lack of research that standardizes parameters for massive transfusions leads teams to evaluate different clinical standards based on different emergency services.

Goal: To discuss, through the scientific literature, the association between the balance of the intestinal microbiota and the emergence of neurodegenerative disorders, especially Alzheimer's disease (AD). Methods: Literature review carried out from October to November 2022 through searches in the following PubMed database. 248 articles were selected and, after inclusion criteria, 17 studies were selected to compose this review. Review: The different studies analyzed indicate that the microbiota-intestine-brain axis is closely interconnected and involved in neural and brain functioning. Its participation consists of processes of cognitive regulation and aging processes, which are directly related to intestinal dysbiosis and its repercussions at the level of the central nervous system (CNS). Intestinal dysbiosis may be in the process of biological senescence and culminate in chronic systemic inflammation, with the potential for brain beta-amyloid aggregation. Final Considerations: There is an imbalance of the intestinal microbiota that is related to neurodegenerative diseases. As the pathophysiology of AD is multifactorial, it is still necessary to deepen studies on this relationship to aid in early diagnosis and treatment.

Esse artigo buscou revisar sistematicamente as opções farmacológicas e as principais intervenções da área psicossocial para o tratamento eficaz de pacientes portadores de transtorno afetivo bipolar (TAB), relacionando a importância da adesão contínua do paciente ao tratamento. Sabe-se que indivíduos portadores de TAB apresentam redução na expectativa de vida, além de risco maior de mortalidade quando comparados à população geral. Sendo assim, estudos mostram que o tratamento farmacológico de longo prazo é fundamental para a remissão dos sintomas. O lítio é a droga de primeira linha, considerada padrão ouro para tratamento do TAB. A depender do caso, pode-se associar o lítio a outros medicamentos, tais como os antipsicóticos de segunda geração. Apesar de muito avançada, a terapia farmacológica no TAB ainda apresenta limitações uma vez que a adesão dos pacientes é precária. Por outro lado, as intervenções psicossociais que abrangem a psicoeducação de paciente e familiares, psicoterapia e suporte social, têm se mostrado bastante efetivas na redução das taxas de evasão e no aumento dos níveis de adesão terapêutica. Dessa forma, as intervenções psicossociais apresentam-se como ferramentas úteis para incentivar e auxiliar os pacientes, uma vez que a contenção dos sintomas pela terapia medicamentosa é fundamental para a funcionalidade do indivíduo.