With much advancement in the field of nanotechnology, bioengineering and synthetic biology over the past decade, microscales and nanoscales devices are becoming a reality. Yet the problem of engineering a reliable communication system between tiny devices is still an open problem. At the same time, despite the prevalence of radio communication, there are still areas where traditional electromagnetic waves find it difficult or expensive to reach. Points of interest in industry, cities, and medical applications often lie in embedded and entrenched areas, accessible only by ventricles at scales too small for conventional radio waves and microwaves, or they are located in such a way that directional high frequency systems are ineffective. Inspired by nature, one solution to these problems is molecular communication (MC), where chemical signals are used to transfer information. Although biologists have studied MC for decades, it has only been researched for roughly 10 year from a communication engineering lens. Significant number of papers have been published to date, but owing to the need for interdisciplinary work, much of the results are preliminary. In this paper, the recent advancements in the field of MC engineering are highlighted. First, the biological, chemical, and physical processes used by an MC system are discussed. This includes different components of the MC transmitter and receiver, as well as the propagation and transport mechanisms. Then, a comprehensive survey of some of the recent works on MC through a communication engineering lens is provided. The paper ends with a technology readiness analysis of MC and future research directions.Comment: Accepted for publication in IEEE Communications Surveys & Tutorial

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One of the key enablers of future wireless communications is constituted by massive multiple-input multiple-output (MIMO) systems, which can improve the spectral efficiency by orders of magnitude. However, in existing massive MIMO systems, conventional phased arrays are used for beamforming, which result in excessive power consumption and hardware cost. Recently, reconfigurable intelligent surface (RIS) has been considered as one of the revolutionary technologies to enable energy-efficient and smart wireless communications, which is a two-dimensional structure with a large number of passive elements. In this paper, we propose and develop a new type of high-gain yet low-cost RIS having 256 elements. The proposed RIS combines the functions of phase shift and radiation together on an electromagnetic surface, where positive intrinsicnegative (PIN) diodes are used to realize 2-bit phase shifting for beamforming. Based on this radical design, the world's first wireless communication prototype using RIS having 256 2-bit elements is designed and developed. Specifically, the prototype conceived consists of modular hardware and flexible software, including the hosts for parameter setting and data exchange, the universal software radio peripherals (USRPs) for baseband and radio frequency (RF) signal processing, as well as the RIS for signal transmission and reception. Our performance evaluation confirms the feasibility and efficiency of RISs in future wireless communications. More particularly, it is shown that a 21.7 dBi antenna gain can be obtained by the proposed RIS at 2.3 GHz, while at the millimeter wave (mmWave) frequency, i.e., 28.5 GHz, a 19.1 dBi antenna gain can be achieved. Furthermore, the over-the-air (OTA) test results show that the RIS-based wireless communication prototype developed is capable of significantly reducing the power consumption.

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