We report an ion flux dependence study of the Si dot pattern formed on Si(100) by
Ar+
ion sputtering with the ion energy being 1.5 keV, ion dose
5 × 1017 ions cm−2, and ion flux
ranging from 280 to 1100 µA cm−2. Experimental results show that the lateral dot diameter
d and the
ion flux f
basically follow the relationship of , and the surface roughness w
decreases with increasing f
in an exponential decay manner. Simulations based on a widely accepted continuum
model, namely the noisy Kuramoto–Sivashinsky equation, reproduced the trend for
d versus
f but failed to
explain that for w
versus f. A redeposition consideration was then suggested. It is found that with this correction not only are
the d–f
and w–f
relationships well explained, but the simulated surface morphology bears closer resemblance
to the experimental one as well. The effect of redeposition becomes important for
f> ∼130 µA cm−2
as derived in this work.
BackgroundParaneoplastic syndromes (PNSs) are common complications of lung cancer and often develop preceding the diagnosis of primary malignancy. Rheumatologic PNSs mimicking Adult-Onset Still' s Disease (AOSD) is a rare condition with only a limited number of cases reported in the literature, none of which was associated with lung cancer. It is often difficult to differentiate AOSD-like paraneoplasia from coincidental AOSD based on the clinical manifestations.Case presentationHere we present a 56-year-old man with advanced lung adenocarcinoma who developed a remittent fever together with pharyngodynia and joint pain after first cycle of chemotherapy with paclitaxel plus carboplatin. Although a leukocytosis was detected, no evidence of infection was acquired and empirical antibiotic treatment was ineffective. A temple skin rash, abnormal hepatic function and a remarkable elevated level of serum ferritin occurred later in this patient, which highly supported a potential diagnosis of AOSD. The patient was finally diagnosed as AOSD-like PNS considering the good and prompt response to a short-term administration of non-steroidal anti-inflammatory drug and subsequent cycles of effective chemotherapy with pemetrexed plus cisplatin.Discussion and conclusionsThough rare, AOSD-like PNS can be one of the potential diagnoses in lung cancer patients with fever of undetermined origin, especially those having no response to antibiotic treatment. Management consists of control of the underlying malignancy and symptomatic treatment of the syndromes with non-steroidal anti-inflammatory drugs or corticosteroids.
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