In pharmaceutical research, the percutaneous route of drug has gained a great interest. Percutaneous delivery has enhanced a noval vesicular drug carrier system called transferosome introduced in 1990, which is composed of water, surfactant and phospholipid. The elasticity of vesicular transferosome is more than the standard liposome therefore well suited for the penetration into the skin. The transferosomes can be prepared by Reverse Phase Evaporation method, Modified Hand Shaking, Lipid Film Hydration Technique and Thin Film Hydration Technique. This article is focused on various drug lists which easily accommodate in transferosome. Transferosome application areas included Delivery of Insulin, Carrier for Interferons & Interlukin, Transdermal Immunization, and Carrier for Other Proteins & Peptides, Peripheral Drug Targeting, Transdermal Immunization, Delivery of NSAID, and Delivery of steroidal hormones etc. To overcome problems of systemic toxicity associated with targeting therpy, enhance treatment resolution of targeting therapies.

Natural products having medicinal value are gaining more importance in clinical research now days due to their better pharmacological response and no side effects as compared to allopathic drugs. Tinospora cordifolia common name is "Guduchi" or "Giloy" is known for its application in the treatment of various diseases in the traditional ayurvedic literature. Active components obtained from the plant and their biological function in disease control has led to active interest in the plant. This review contains venicular name of plant, various components, their uses in targeting diseases .Giloy is an very important plant for treatment of various diseases.