Mixing intravenous preparation especially in patients intensive care unit (ICU) at the hospital requiring special attention relating to their higher had medication errors, as nosocomial infection and incompatibility drugs. Things that need to be considered in mixing sterile preparations, namely compounding personnel, facilities and infrastructure and the process of mixing sterile preparations. This study aims to calculate the percentage of suitability for the mixing process for intravenous preparations based on the Basic Guidelines for Dispensing Sterile Preparations, Guidelines for Injectable and Cytostatic Drugs in 2009 and the Handbook of Injectable Drugs Edition 16th for Intensive Care Unit (ICU) patients at the hospital “X” Samarinda. The research is descriptive research using sheets observational data collection. The subject of research is do mixing, facilities, and infrastructure as well as mixing procedure. The results of observations as many 215 processes of mixing intravenous preparations observed in the ICU showed that 100% of compounding personnel were carried out by nurses, and 100% of infrastructure did not have a clean room, LAF, and pass box, 53% carried out the mixing process according to procedures, and physical quality tests. drug preparations are 100% in accordance with the Handbook of Injectable Drugs Edition 16th, namely the preparations produced are clear and free of foreign particles.