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A Obesidade é um fator de risco para doenças cardiovasculares e a sua prevalência cresce a cada ano atingindo mais de 2 bilhões de adultos no mundo. As principais recomendações para perda de gordura concentram-se em exercícios de estados estacionários de intensidades moderadas. Entretanto, essas diretrizes não conseguem ser atendidas pela maior parte da população adulta. Sendo assim, novas modalidades ou intensidades de exercícios vem sendo propostas na tentativa de promover perdas mais significativas da gordura corporal. Foi realizado uma revisão sistemática com meta-análise com o objetivo de comparar os efeitos do treinamento intervalado de alta intensidade (HIIT) e do treinamento contínuo nos desfechos: massa corporal total, percentual de gordura, índice de massa corporal e circunferência de cintura de indivíduos com sobrepeso e/ou obesidade. As buscas foram realizadas nas bases de dados Pubmed, Science Direct, PEDro, Scielo e Cochrane Library. A análise foi restrita a ensaios clínicos randomizados em adultos com 18 anos de idade ou mais e com excesso de peso corporal. As meta-análises foram conduzidas utilizando o software Review Manager para modelos de efeitos aleatórios com o método do inverso da variância para os dados contínuos, os dados foram apresentados por diferença da média e IC95%. Quatorze estudos foram incluídos para a análise meta-analítica, houve redução significativa para o grupo CONT para circunferência de cintura (1,19 cm; IC95%: 0,34–2,04; p= 0,006; I2= 0%). Em conclusão, o HIIT não se mostrou melhor estatisticamente em relação ao CONT para alterar os marcadores da composição corporal.

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Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most popular drugs in the world for treating pain and inflammation. Although the long-term use of NSAIDs is associated with adverse renal, cardiovascular, hepatic, and other effects, it has also been suggested that may cause impairing neuromuscular adaptations promoted by exercise. Objective: The objective of this systematic review was to compare the effects of NSAIDs use in neuromuscular adaptations, such as hypertrophy and muscle strength in middle-aged and elderly practitioners of resistance training. Methods: The databases included Bireme, Pubmed e Science Direct. Meta-analyses were conducted using the robust variance estimation of correlated effects with small-sample adjustments. Results: Six studies were included for meta-analytical analysis. No statistical differences were found for hypertrophy (ES: 0.000531 ± 0.0424, 95%CI: -0.123 – 0.124; P = 0.991) and muscle strength (ES: 0.323 ± 0.213, 95% CI: -0.417 – 1.06; P = 0.258). Conclusion: The findings of this review do not support the hypothesis that the use of NSAIDs combined with resistance exercise negatively influences the hypertrophy and muscle strength.Keywords: non-steroidal anti-inflammatory agents, resistance training, hypertrophy, muscle strength, aged.

Non-alcoholic fatty liver disease is growing in worldwide prevalence and thus, is expected to have a higher number of NAFLD-related hepatocellular carcinoma (HCC) in the following years. This review describes the risk factors associated with HCC in NAFLD-patients. The presence of liver cirrhosis is the preponderant one. Male gender, PNPLA3 variants, diabetes, and obesity also appear to predispose to the development of HCC, even in non-cirrhotic subjects. Thus far, intensive lifestyle modifications, including glycemic control, and obesity treatment, are effective therapies for NAFLD/ non-alcoholic steatohepatitis and, therefore, probably, also for HCC. Some drugs that aimed at decreasing inflammatory activity and fibrosis, as well as obesity, were studied. Other data have suggested the possibility of HCC chemoprevention. So far, however, there is no definitive evidence for the routine utilization of these drugs. We hope, in the future, to be able to profile patients at higher risk of NAFLD-HCC and outline strategies for early diagnosis and prevention.