Diabetes mellitus (DM), with the main manifestation of hyperglycemia, is a metabolic disease associated with carbohydrate, protein, and fat metabolism disorders. A new treatment that can improve the activity of key enzymes in carbohydrate metabolism is promising in controlling blood glucose. Murraya koenigii (MKE) has been proven to control blood sugar in diabetic rats. This study examined MKE's performance mechanism by examining the primary enzymes' activities in carbohydrate metabolism and the glucose transporter type 4 (GLUT4) expression of the liver and skeletal muscle in streptozotocin-nicotinamide-induced diabetic rats. This study used the liver and skeletal muscle of rats (n = 30), divided into six groups: normal, normal + MKE (400 mg/kg), DM, DM + MKE 200 mg/kg, DM + MKE 400 mg/kg, and DM + glibenclamide. This study revealed that the activity of hexokinase and glucose-6-phosphate (G6Pase) dehydrogenase decreased, and the activity of the G6Pase and phosphoenolpyruvate carboxykinase-1 enzymes increased in the liver of DM rats. In addition, GLUT-4 expression in the skeletal muscle of hyperglycemic rats also decreased. The administration of MKE 200 and 400 mg/kg b.wt. could improve the enzyme activity, equivalent to a group of normal rats. Moreover, GLUT-4 expression also increased in MKE-administered rats. MKE exhibited an antihyperglycemic effect by improving key enzymes on carbohydrate metabolism and increased GLUT-4 expression against hyperglycemic rats.

Kimpul tubers have anti-nutritional substances in the form of calcium oxalate (CaC2O4) which when consumed will cause itching sensations in the skin, mouth, throat and digestive tract. Calcium oxalate content in kimpul tubers is 1,740 mg / 100 g. The safe limit for consuming oxalate for adults is 0.60-1.25 g per day for 6 consecutive weeks. In this research, a combination of physical and chemical methods will be carried out with taro varieties, namely Umbi Kimpul (Aceh Besar). Physical treatment (boiling and steaming) and followed by immersion treatment with chemicals (6% sodium bicarbonate, 20% acetic acid and 10% sodium chloride) are thought to affect the decrease in calcium oxalate in taro. The lowest oxalate content of kimpul tuber flour was obtained, namely 13.62 mg / 100 g of the material from the boiling treatment by soaking in 20% CH3COOH. While the steaming treatment with the lowest levels of calcium oxalate in kimpul tuber flour, namely 22.28 mg / 100 g after soaking in 6% NaHCO3. The two values obtained from the test results were lower than the calcium oxalate content of fresh kimpul tubers, which was 42.35 mg / 100 g.

COVID-19 has been declared a pandemic and continues to spread, leading to health and economic problems and economic burdens worldwide. COVID-19 symptoms are similar to the flu and, in severely infected patients, emerge as an acute respiratory syndrome (ARDS), pulmonary fibrosis, edema, and even organ failure. These are due to an imbalanced immune response with a more severe effect than the virus attack. However, no specific medications and treatments are available in dealing with the COVID-19. Hence, mesenchymal stem cell (MSC) treatment is proposed as one therapeutic approach. The MSCs can produce growth factors and immune protective cytokines that could fight viral infection and are proven to help endothelial cell repair. These capabilities are expected to help resist viruses and tissue repair in a patient body. MSC is believed to prevent acute respiratory infections, the most dangerous stage of COVID-19 pathogenesis. In this study, we collect some literature, reviewing and summarizing them so that we believe that MSC could be an approach to cure COVID-19 patients and improve their responses to the virus. This article reviews the use of mesenchymal stem cells as a potential therapy for COVID-19, and this information can also be used as basic information for developing a stem-cell-based therapy, especially for treating COVID-19.

Gaya hidup tidak aktif merupakan salah satu faktor penyebab terjadinya sindroma metabolik. Komplikasi sindrom metabolik seperti penyakit jantung dan diabetes melitus terus mengalami peningkatan. Mahasiswa perlu memiliki pengetahuan dan tingkat aktivitas fisik yang baik agar dapat menekan angka kejadian sindrom metabolik di kemudian hari dan menjadi teladan bagi sekitarnya. Pengetahuan yang baik dapat memperbaiki tingkat aktivitas fisik. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan tentang sindrom metabolik dan  aktivitas fisik yang tepat dengan tingkat aktivitas fisik. Penelitian ini merupakan  penelitian cross sectional pada mahasiswa S1 setiap fakultas di Universitas Syiah Kuala angkatan 2017 dengan metode proporsional simple random sampling. Data tingkat pengetahuan diambil dengan menggunakan kuesioner pengetahuan yang telah di validasi dan data tingkat aktivitas fisik diperoleh dari Global Physical Activity Questionare (GPAQ). Dari hasil penelitian didapatkan 57,1 % responden memiliki aktivitas fisik yang rendah dan 89,7% memiliki pengetahuan yang tinggi. Tidak terdapat hubungan yang signifikan antara tingkat pengetahuan dengan tingkat aktivitas fisik (p = 0,795) pada mahasiswa S1 angkatan 2017 di Universitas Syiah Kuala.

Computer Vision Syndrome (CVS) is a collection of symptoms related to computer use prolonged. This can occur from various factors consisting of individual factors, computer factors and environmental factors. Computer engineering students are a group of students who use computers in doing assignments and other activities in daily life. The purpose of this study was to determine the risk factors for CVS events in students of the Computer Engineering Study Program, Syiah Kuala University. This research is an observational analytic survey with a cross sectional. The sample used consisted of 164 students from the 2017-2019 class who were taken by the stratified random sampling method. Collecting data through self-assessment using a questionnaire. Statistical test using Chi square test for bivariate and to find out which risk factor is the most influential, multivariate analysis is used, namely logistic regression analysis. The results showed that 63.4% of Computer Engineering Students at Syiah Kuala University experienced CVS. The factors that were significantly associated with the incidence of CVS were gender (p=0.03), duration of computer use (p=0.01) and eye distance to the monitor (p=0.001).