analysis of published data on genetic polymorphisms and biochemical mechanisms of genital prolapse is presented. The paper prasents the modern data on the impact of genetic polymorphisms on genital prolapse predisposition. It describes appropriate molecular genetic and biochemical processes of pathological connective tissue formation of pelvic organs and the pelvic complex in women with genital prolapse, including the background of connective tissue dysplasia syndromе.

Objective: To study the presence of gene polymorphisms of extracellular matrix structural components and metabolism enzymes, receptors activity and mechanisms of intracellular regulation of the connective tissue in women with genital prolapse.Subjects and methods: Analysis of published data on genetic polymorphisms and biochemical mechanisms of genital prolapse is presented. Results:The paper presents the morden data on the impact of genetic polymorphisms on genital prolapse predisposition. It describes appropriate molecular genetic and biochemical processes of pathological connective tissue formation of pelvic organs and the pelvic complex in women with genital prolapse. Conclusion:Genital prolapse is a multifactorial pathology with various pathological both extra-and intracellular mechanisms. At the moment, a lot of genetic variants are not specific only for this disease. There is no uniform consensus on the pathogenesis of the disease. Therefore, it is necessary to identify the specific molecular genetic markers of susceptibility to genital prolapse and identify high-risk groups, as well as the result prediction of surgical treatment.

The purpose of study. To analyze genetic polymorphisms of receptors of bladder, structural components of intercellular matrix of urinary excretion organs, molecular biochemical mechanisms of regulation of function of bladder and urethra resulting in urinary incontinency. Materials and methods. The analysis of publication data concerning genetic polymorphisms and molecular biochemical mechanisms of development of urinary incontinence in women. The results. The publication data is presented concerning impact of genetic polymorphisms of receptors of detrusor on development of urgent and mixed urinary incontinency in women. The corresponding molecular genetic and biochemical processes underlying detrusor sphincter dyssynergia in women are considered. Conclusion. The urinary incontinence is a multifactorial pathology developing due to alterations at systemic, organic, tissular and cellular levels. Such growth factors as bFGF, TGFβ, CTGF contribute into pathogenesis of urgent and partially mixed urinary incontinency resulting in intensification of unstripped muscle cohesions of detrusor, obstructive miohypertrophy and fibrosis of bladder wall. The altered adrenalin reactivity of urinary excretion ways plays particular role in pathogenesis of urgent component of urinary incontinence. And vice versa, damage of structure of connective tissue in patients with polymorphism COL1A1 or disorder of molecular biochemical mechanism of action of cytokines TGFβ and CTGF provoke insufficiency of sphincter apparatus of urinary excretion ways. The totality of enumerated mechanisms results in development of stress urinary incontinency. The elaboration of individual approach to selection of treatment method requires consideration of mentioned mechanisms of development of urinary incontinence including form and severity of disease.

The purpose of study. To explore input of vegetative nervous system, fatty tissue as endocrine organ and further inter-tissue interactions in pathogenesis of syndrome of polycystic ovary. The material and methods. The analysis of publication data concerning prevalence of syndrome of polycystic ovary in women with normal body mass and obesity and also about involvement of neural regulation, molecular genetic and biochemical mechanisms in development of syndrome of polycystic ovary. The results. The publication data is presented concerning effect of sympathic adrenal system on fatty tissue and ovary under syndrome of polycystic ovary. The characteristics of synthesis of growth factors are considered including their effect on development of insulin resistance resulting in subsequent hyperinsulinemia in female patients with the given syndrome. The conclusion. The syndrome of polycystic ovary is a wildly prevalent multi-factorial pathology conditioned by both genetic and environmental factors. The particular role in pathogenesis of this syndrome play alterations of vegetative regulation, carbohydrate metabolism and steroidogenesis. The review presents data concerning effect of totality of growth factors and sympathic innervation of development of clinical manifestations of the syndrome of polycystic ovary.