Our previous study demonstrated berberine (BBR) and fluconazole (FLC) used concomitantly exhibited a synergism against FLC-resistant Candida albicans in vitro. We also suggested BBR played a major antifungal role in the synergism of FLC and BBR, while FLC increased intracellular BBR concentrations. Our following systematic structural modification and reconstruction of BBR core identified the novel scaffold of N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(substituted phenyl)acet-amide derivatives 7a-i, including B-7b and B-7d exhibiting remarkable synergistic antifungal activity and low cytotoxicity. Here, the study mainly investigated the synergistic activity of FLC and B-7b and the underlying mechanism. In vitro interaction of FLC and B-7b was investigated against 30 FLC-resistant clinical isolates of C. albicans and non-C. albicans species, including Candida tropicalis, Candida parapsilosis, Candida glabrata, Candida krusei and Cryptococcus neoformans. The potent synergistic activity of B-7b in combination with FLC against FLC-resistant C. albicans was found through the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed its better synergism with FLC. And as expected, B-7b exhibited much lower cytotoxicity than BBR to human umbilical vein endothelial cells. In contrast to BBR, we found that endogenous ROS augmentation was not involved in the synergism of FLC and B-7b. According to the results from our present comparative proteomic study, it seemed that the disruption of protein folding and processing and the weakening of cells’ self-defensive ability contributed to the synergism of FLC and B-7b. Together, these results suggested novel scaffold BBR derivative B-7b could be a promising synergist in combination with FLC for the treatment of invasive fungal infections.

The characteristics of the continuous wavelet transform scalogram of the aeroengine vibration signal could show the fault symptomatic in the 2-dimensional space and identify the rub-impact fault of the aeroengine. In order to get the precise feature for fault analysis, the statistical features of the scalogram which incorporated the Tamura vision features were proposed to diagnose the aeroengine rub-impact faults quantitatively. The experiments on the aeroengine test data demonstrate these statistic characteristics of the scalogram effectively diagnose the rub-impact faults.

Wide stainless steel hot strip line integrated with mechanical electric hydraulic equipments is a complicated large system. Automatic control system is very important for improving mill efficiency and products quality. The new equipments and technology are introduced. The characteristics of hot strip line and its requests for automation, the ideas of control system design, system structure and configuration are explained in detail. Multilevel system, 1000M high speed fabric Ethernet between levels, 640M high speed global data memory network between controllers, high speed Profibus_DP network between controller and equipments, hot machine backup strategy of L2,Tri-cyclic fabric Ethernet redundancy of L1 and other innovative design ideas,and L2 main mathematic models, L1 key control models are all applied in the system. The design ideas of this paper and integrated automatic control system has been applied on several stainless steel hot strip lines.

According to the arrangement of laminar cooling equipment in Desheng 1150mm hot strip mill, two-dimensional finite difference method has been used for coiling temperature online control model basing on the analysis of heat transfer characteristics, practical data are used to optimize water heat coefficient for self-learning as amended, this model are used to calculate the steel temperature change and distribution in the process of laminar cooling. Analysis of different cooling strategies on the cooling rate and organization of steel show that: In the same number of opened cooling tubes, the cooling capacity is not the same in the different strategies, the cooling to back direction is the strongest, followed by intermittent cooling, the cooling to front direction is the smallest. Cooling strategy was applied to the scene and simulated results match with the actual observation. The system has a wide range of cooling rate adjustment, the operation and control is well, which meet to the development and the requirements of new varieties.

A three-dimensional dynamic simulation model of the molten iron flow field was presented in the paper with Fluent simulation software. Different operating parameters combinations, including different oxygen lance locations, oxygen pressures and oxygen flows, different arrangements of bottom blowing holes, hole sizes, nitrogen pressures and nitrogen flows were studied. It is shown that the relative optimum value of the distance from top-blow gun to the molten iron surface is 1500 mm, and bottom blowing hole diameter is 20mm, there is no significant difference of the blowing effects found when comparing single ring arrangement with double rings arrangement of 8 bottom blowing holes with only bottom-blow, and the bottom-blow of inner ring is disturbed by top-blow when top and bottom combined blow. Optimized design results have been applied to the design and manufacture of the actual converter, the converter has been successfully used in plant. The actual production results indicate that the desiliconization precision can reach 0.05%, the content of Cr2O3 in the slag after reduction can be less than 2%, better than the technical requirements of 3%, and improve the recovery rate of the chromium. Compared with traditional desiliconization method by iron gutter and iron ladle, desiliconization by converter does not use compression residue agents and reduce the amount of desiliconization agents and slag, and improve the desiliconization efficiency and productivity.