This paper develops a location-allocation model to optimize a four-echelon supply chain network, addressing manufacturing and distribution centers location, supplier selection and flow allocation for raw materials from suppliers to manufacturers, and finished products for end customers, while searching for system profit maximization. A fractional-factorial design of experiments is performed to analyze the effects of capacity, quality, delivery time, and interest rate on profit and system performance. The model is formulated as a mixed-integer linear programming problem and solved by using well-known commercial software. The usage of factorial experiments combined with mathematical optimization is a novel approach to address supply chain network design problems. The application of the proposed model to a case study shows that this combination of techniques yields satisfying results in terms of both its behavior and the obtained managerial insights. An ANOVA analysis is executed to quantify the effects of each factor and their interactions. In the analyzed case study, the transportation cost is the most relevant cost component, and the most relevant opportunity for profit improvement is found in the factor of quality. The proposed combination of methods can be adapted to different problems and industries.

In this study, an industrial process is proposed to produce Fe 3 O 4 nanoparticles with a high specific absorption rate. The analysis was focused on the theoretical study of the dynamic performance in a continuous stirred tank reactor system, using the chemical kinetics of the reaction, which was obtained experimentally in the present work. For this purpose, nanoparticles with different sizes were prepared varying the reaction time by the thermal decomposition method. Subsequently, their physical and chemical properties were characterized by X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy, and magnetic measurements. The results obtained suggested that this material could be used in magnetic hyperthermia; for this reason, the nanoparticles were functionalized with DMSA through a binder exchange reaction. Afterward, the specific absorption rate of the ferrofluid was determined under an applied AC magnetic field (17.5 kA/m, 153 kHz), obtaining a value of 109.75 W/g. To produce these nanoparticles industrially, the use of two CSTRs connected in series was considered because one was required for the nucleation zone and another for the growth zone. The heating in each of the reactors was carried out by a set of electrical resistances regulated by a feedback control system, using PI controllers, which were tuned minimizing the IAE through the stochastic method of simulated annealing. The preheating in each stream that fed each reactor and the cooling in the output stream of the second reactor were through heat exchangers. The results indicate that the proposed process is appropriate because the dynamic responses in both reactors do not present higher oscillations when the temperature is disturbed in each of the currents that feed to the reactors. Also, the stabilization time in the temperature of the CSTRs is not greater than 10 min, which leads to a reasonable control of the particle size during its production, since the size is a function of the reaction time and temperature. Therefore, these Fe 3 O 4 nanoparticles are suitable to be applied in magnetic hyperthermia and produced by the proposed process.

El artículo de investigación muestra la identificación de características de mayor impacto en empresas medianas de México y Colombia frente a la Calidad,Competitividad, Innovación Social y Productividad, el tipo de investigación aplicada es cuasiexperimental, el corte de la investigación es cuantitativo, encuesta Delphi aplicad a 35 expertos del tema en Colombia y México, el diseño de la investigación es transversal, el alcance de la investigación es descriptivo de las variables teóricas calidad, innovación social y competitividad y análisis estadístico de datos con el software R®, finalmente el uso de herramientas de la calidad en las empresas medianas de México y Colombia en la implementación de estrategias de calidad evidencia que satisfacen las necesidades de la comunidad interna y externa de las entidades desde la planeación estratégica en los sistemas de gestión de calidad con innovación social y productiva fortaleciendo los procesos, procedimientos y la seguridad social del capital humano en medianas empresas de Colombia y México.

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El presente documento pretende mostrar un estudio sobre la propuesta de implementación de la Planificación de Recursos Empresariales (PRE) o Enterprise Resource Planning (ERP) y dela Gestión de Clientes(GC) o Customer Relation Management (CRM) en una institución educativa, considerando las etapas de: diagnóstico situacional, diseño de la solución e implementación de la solución aplicado al análisis en una institución educativa universitaria para evaluar la apreciación que se tiene sobre el desempeño actual de la infraestructuray operación de las tecnologías de información con énfasis en un ERP con el cual, opera en especial en su CRM bajo el enfoque de evaluar lo funcional y eficiente que resulta su operabilidad para dar servicio al cliente, por medio de utilizar el análisis Fuerzas, Oportunidades, Debilidades y Amenazas (FODA) para su evaluación, incluyendo la propuesta y la implementación de la solución por medio de las distintas etapas necesarias paragarantizar una propuesta confiable de un proyectos exitoso, dentro de las cuales están de manera general las etapas de: diagnóstico, planificación, ejecución y evaluación, las cualesbrinda el caso de aplicación de la metodología para la gestión de la propuesta en donde cada una de la etapas, contienen sus subetapas, como resultado de ello se generan los módulos necesarios y sus sub módulos que integraran las solución para mejorar el seguimiento de los procesos de la institución educativa.