The estimated national prevalence of non-celiac gluten sensitivity is 0.548%, approximately half that of celiac disease. Future studies are merited in order to better understand the population burden of non-celiac gluten sensitivity.

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Goals To determine whether patients with celiac disease and low vitamin D levels also have a higher prevalence of other autoimmune diseases (AD) as compared to patients with normal vitamin D levels. Background Patients with CD carry a higher risk of other autoimmune disorders. Because of its immunoregulatory properties, vitamin D deficiency has been proposed in the pathogenesis of a variety of AD. Whether low vitamin D levels in patients with CD can predict concomitant AD is unknown. Study A retrospective cross-sectional study of 530 adult patients with CD and a 25-hydroxyvitamin D level on record at CUMC. Results 133 patients (25%) had vitamin D deficiency. The prevalence of AD was similar among those with normal vitamin D (11%), insufficiency (9%), and deficiency (12%, p=0.66). On multivariate analysis, adjusting for age of CD diagnosis and gender, vitamin D deficiency was not associated with AD (OR 1.35 95% CI 0.62–2.95). The risk of psoriasis was higher in patients with vitamin D deficiency (7% vs. 3%, p=0.04). Vitamin D deficiency was more common in those who presented with anemia (39%) than in those who did not (23% p=0.002). Conclusion Vitamin D deficiency in CD is common but does not predict AD. Psoriasis is increased in vitamin D deficient CD patients. Assessment of vitamin D appears to be a high-yield practice, especially in those CD patients who present with anemia.

PN is more often found in patients with CD and/or IBD than in the general population.

The proportion of individuals HLA DQ2/8 positive is higher in those with liver/upper functional GI disease and lower in IBS/IBD as compared to general population estimates.