Background: In Chile we also consider surgery as a treatment in the hepatic metastases of colorectal cancer. We present the first series that measures the Chilean genetic profile. Methods: We reviewed the clinical records of all colorectal cancers operated in our center from 2005 to the present. Conclusion: We found a RAS mutation is very common in our population. Which is a bad genetic factor in our population. P 219 CEPHALIC DUODENOPANCREATECTOMY RESECTION: TECHNIQUE, MORBIDITY AND MORTALITY

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Introduction: Between 20 and 40% of liver metastases from colorectal tumor are synchronous. Three types of surgical approaches are proposed; two of them propose a deferred resection and the other, simultaneous resection. The aim of this analysis is to assess the short-and long-term outcomes of simultaneous resections. Method: 212 synchronous liver metastases resected in two centers were evaluated. Comparison between those resected simultaneously with those that were in a deferred way was made. Demographics, liver resections and metastatic characteristics were evaluated. Morbidity and mortality of both alternatives are also evaluated. Results: 63 patients were resected simultaneously with the primary tumor, there were no significant differences in demographic characteristics. There was a greater number of major resections (p = 0.005) in the deferred group. Morbidity and mortality were comparable in both groups. Liver failure (p = 0.037) was higher in the deferred group. Morbidity was 33.2% in the deferred and 10.1% for the simultaneous (p = 0.256). Mortality rate was 2.83% in the deferred and 0.94% in the simultaneous group (p = 0.508). Conclusion: Short and long-term outcomes for both groups are similar. A question remains to be answered: the need of a major hepatectomy will favor the election of a deferred treatment?

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Antecedentes: Los procedimientos laparoscópicos ganaron popularidad porque favorecen una recuperación rápida. El establecimiento de programas ERAS (Enhanced Recovery After Surgery) en cirugía mayor abdominal ha acortado la estancia hospitalaria independientemente de la vía de abordaje. Varios trabajos informan los resultados sobre programas ERAS aplicados a hepatectomías abiertas o laparoscópicas, o comparando una de ellas con el abordaje clásico, pero pocos han comparado los resultados entre ambas dentro de un programa ERAS. Objetivo: Comparar, dentro un mismo programa ERAS, los resultados entre hepatectomías abiertas y laparoscópicas. Método: Se incorporaron a este estudio 36 pacientes sometidos a hepatectomías que fueron abordados por vía laparoscópica o abierta dentro de un programa ERAS. Los objetivos primarios fueron la estancia hospitalaria y el número de complicaciones. Resultados: No hubo diferencias significativas entre ambos grupos en cuanto a estancia hospitalaria ni número de complicaciones. Las diferencias radicaron en un menor tiempo de cirugía y una deambulación más precoz a favor de la cirugía abierta, y una recuperación total mejor a favor del abordaje laparoscópico. Conclusiones: Los datos iniciales sugieren que no habría beneficios en cuanto a estancia hospitalaria e índice de complicaciones de las hepatectomías laparoscópicas sobre las abiertas dentro de un programa ERAS.