No abstract

Background: Previous studies have demonstrated that the C-reactive protein to albumin ratio (CAR) is correlated with the clinical outcomes of solid tumors. However, the available data have not been systematically evaluated. The objective of the present meta-analysis was to explore the prognostic value of the CAR in solid tumors. Methods: Eligible studies were identified from the PubMed, EMBASE and Web of Science electronic databases. The clinical characteristics, disease -free survival (DFS) /progression-free survival (PFS) and overall survival (OS) were extracted from the eligible studies. The pooled hazard ratios (HRs) and 95% confidence intervals were calculated with STATA 12.0 software. We also performed subgroup, meta-regression and sensitivity analyses. Results: In total, twenty-seven eligible studies including 10556 patients were enrolled in the present meta-analysis. The pooled HRs with 95% confidence intervals showed that the CAR was significantly associated with poor OS (HR = 1.95, 95% CI: 1.71–2.22) and DFS/PFS (HR = 1.82, 95% CI: 1.61–2.07) in patients with solid tumors. Although publication bias was found in the studies with regard to OS, a further trim and fill analysis revealed that the adjusted HR was 1.82 (95% CI: 1.69–1.96), which was close to the original HR. Subgroup analysis confirmed the CAR as a strong prognostic marker in patients with solid tumors, regardless of the tumor type, detection time, cut-off value, sample size and area. Conclusion: Our meta-analysis indicated that a high CAR might be an unfavorable prognostic marker for OS and DFS/PFS in patients with solid tumors.

With the typical composite roof roadway and roof fall accidents in the Guizhou Province of China as the research background, the expression of damage parameters of composite roof was deduced according to Weibull statistical distribution, generalized Hooke’s law and Mises yield criterion, and the influence of shape and scale parameters of Weibull on damage characteristic was discussed. Based on the infinite slab theory, the expressions of deflection and layer separation of each layer of the composite roof were obtained, the critical load expression of each delamination was determined, and the influence of roadway width, overlying strata load, elastic modulus, shape parameters and scale parameters on the stability of composite roof was explored. The research shows that the bolt support can effectively reduce the layer separation between the composite roofs and enhance the stability of the composite roof. On this basis, it is proposed that for the surrounding rock control problem of roadways with composite roof, the active support technology with bolts as the core should be adopted.