The subjective well-being on schizophrenic patients is influenced by many aspects, especially family support. However, the influence is not always in a direct affection; it may through self-care. The present study is aimed at finding out the influence of family support toward well-being through self-care as mediator on schizophrenic patients. The subjects of this study were 108 patients of a psychiatric hospital at South Kalimantan. The instruments used were Subjective Well-being Under Neuroleptics Scale (SWNS) to measure the subjective well-being of the subjects, Perceived Social Support-Family Scale (PSS-Fa) to investigate the family support experienced by the subjects, and Self Care Assessment Tools to assess the self care of the subjects. Regression analysis was applied to figure out the influence of exogenous variable toward endogenous variable and to examine the influence model among variables. The result of data analysis revealed that family support possessed higher influence toward the subjective well-being, therefore selfcare could not be the influence mediator of family support toward the subjective well-being on schizophrenic patients.