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Background: Lung cancer is the most common cancer and by far the leading cause of cancer death among both men and women in the world. In Kashmir, in the recent study, Lung carcinoma was found to be second common in males and sixth in females in Kashmir. This study was carried out to study the demography, clinical presentation, risk factors and histopathological pattern of peripheral lung tumours in resected specimens and to evaluate the added advantage of Immunohistochemistry for enhancing the diagnostic accuracy.Methods: It was a five-year study conducted in the Department of Pathology, SKIMS and the cases from June 2009 to April 2012 were analysed retrospectively while the cases from June 2012 to May 2014 were evaluated prospectively. A total of 97 cases with peripheral lung tumor in whom resection was done were studied.Results: Majority of the cases were seen in males (84.53%) in the fifth decade of life. Cough was the most common symptom, present in 58.76% patients. Right lung was involved in majority of the cases, 57.95% and left lung was involved in 42.04 %. Maximum growth size as seen on gross examination was 8 cm and minimum were 1 cms. Most common histopathological subtype was squamous cell carcinoma seen in 64.94% followed by adenocarcinoma seen in 19.58% of the patients. Lymph nodes were involved in 41 cases (52.56%) and were free in 37 patients (47.43%). IHC was done wherever required and was consistent with histopathology.Conclusions: To improve the therapeutic results of lung cancers efforts for early detection and treatment are essential. Timely intervention with the help of surgery, histopathology and immunohistochemistry are hence very helpful.

Chronic liver disease is a disease process of the liver that involves progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis. We first evaluated the 70 percutaneous liver biopsies from patients with a clinically established diagnosis of chronic hepatitis and chronic liver diseases of various etiologies. All biopsies were obtained through percutaneous approach using 16 F biopsy gun (manufactured by Bard) in adults and 18 F in children. . The mean biopsy size was 1.8cm ± 0.20 and a median size was 2cm. Out of the 70 liver biopsies, a total of 24 (34.2%) liver biopsies were less than 1.5cm in size, and 46(65.7%) were ≥ 1.5cm.

Background: Metaplastic breast carcinomas (MBCs) comprise a rare but aggressive subtype of breast cancer and represent less than 5% of invasive breast carcinomas. Histologically, metaplastic breast carcinoma is characterized by the presence of divergent cellular differentiation and heterologous elements, including squamous, spindled, sarcomatoid /pleomorphic, chondroid, and osseous differentiation. Material and Methods: Histopathologic characteristics of 11 cases of metaplastic carcinoma of breast encountered over a period of three years from May 2016 to May 2019 in our institute. Results: We encountered 11 cases of metaplastic breast cancers out of 226 primary breast malignancies. Two were breast conservation surgeries and the rest were modified radical mastectomies. The histopathological patterns encountered included squamous, chondroid, sarcomatoid and mixed histologic subtypes. Median tumor size was 3.5 cm, majority were triple-negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. All except two patients had lymph nodal metastasis. Conclusion: Metaplastic breast carcinoma is a rare type of breast cancer associated with a poor prognosis. Most patients in this series had high-grade, triple-negative tumors and were treated with optimal therapy.

CASE: 45 year old female presenting with pain in the hip joint. Radiology of the hip joint revealed a huge mass arising from the iliac bone infiltrating the surrounding soft tissue. Opinion of tumor arising from bone? Chondrosarcoma was made. Patient underwent hemipelvictomy. Gross specimen showed a huge mass arising from the iliac bone. Cut section showed myxoid and cartilaginous areas. JMS 2013;16(2):99