Summary Grass pollen extract was reacted with glutaraldehyde, and used in the form of a lyrosine adsorbate for the treatment of hay fever. The incidence of systemic reactions was reduced by the chemical treatment to negligible levels, permitting the therapeutic‐schedule to be reduced to three doses without impairment of clinical effectiveness. The levels of pollen‐specific IgG antibody induced by the chemically modified material were similar to those induced by pollen‐tyrosine or by alum‐precipitated pyridine extract. The increase in IgE antibody induced by glutaraldehyde‐pollen‐tyrosine was lower than that induced by pollen‐tyrosine: only the falter achieved significance.

Grass pollen extract adsorbed on to a suspension of L-tyrosine has been tested over 2 years as a treatment for hay fever. Eight-or nine-dose courses terminating at doses of between 1000 and 10,000 Noon units were equally effective when compared either with a placebo or with a pyridine-extracted alum precipitate.

No abstract

It has been shown in a series of 338 hay fever sufferers that about 19% give one or more (up to nine) negative skin test reactions when tested by the prick test technique to extracts of the pollens of twelve of the most widespread British grasses.

No abstract