Specific sensitivity to individual grass pollens in some hay fever patients

Milner, F. H.; Tees, E. C.

doi:10.1111/j.1365-2222.1972.tb01271.x

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…It is easy to obtain potent extracts., and patients sensitive to other trees appear also to have IgE antibodies against birch with a high frequency (Zetterstrom, Fagerberg & Wide, 1972). Allergen extracts of various grasses cross-react in a similar manner (Milner & Tees, 1972;Berglund & Lundkvist, 1973), and timothy was chosen as a representative for the grasses present in Sweden. Food allergens were included in the panel due to their itnportance for children.…”

Section: Discussionmentioning

confidence: 99%

In vitro diagnosis of atopic allergy The occurrence and clustering of positive RAST results as a function of age and total IgE concentration

Björkstén

Johansson

1975

Clin Experimental Allergy

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Specific IgE antibodies were determined on a routine basis in patient sera using the radioallergosorbent test {RAST) with a panel of ten common allergens. Total IgE was also assayed. Of all positive RAST reactions observed, 74",, were against the following allergens: horse and cat epithelium, birch and timothy pollen, and house dust. Clustering (occurrence together with significantly elevated frequencies) accompanied both positive reactions to some animal danders and food allergens. Children in all age groups had significantly more positive food RAST results than adults, and this explains the clustering among food allergen results. Children aged 0-4 years had few positive pollen results. Among those with at least one positive RAST result, the mean number of positive results was 3 3, a figure which did not var>' with age. In the present patient population 37% had a total IgE above the upper reference (normal) limit, and of these 95/n had at least one positive RAST result. A normal or low IgE value was found to be less informative.

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Section: Discussionmentioning

confidence: 99%

In vitro diagnosis of atopic allergy The occurrence and clustering of positive RAST results as a function of age and total IgE concentration

Björkstén

Johansson

1975

Clin Experimental Allergy

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“…It would appear that most grass pollens have a number of common antigens (Milner & Tees, 1972). Lowenstein (1978) showed that immunological partial identity exists between the antigen of timothy and those of cocksfoot, rye and false-oat grass pollens.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the clinical and immunological effects of an alum‐precipitated five‐grass extract with a conjugated two‐grass extract in the desensitization of hay fever

Waclawski

1984

Clin Experimental Allergy

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Summary Thirty‐nine patients with pollen hay fever were randomly allocated to receive either an alum‐precipitated five‐grass extract (Allpyral®) or a two‐grass conjugated extract (Conjuvac®) prior to the 1982 pollen season. Efficacy was assessed by means of symptom scores, drug usage and specific IgE and IgG antibody response. Both nasal and eye symptom scores were significantly higher during the pollen season in those patients receiving Allpyral. Specific IgE and IgG measured after the pollen season showed similar rises in each group. Seven patients showed a marked elevation in specific IgE and nine a marked elevation in specific IgG, but no patient showed both. Those with a high specific IgE level tended to be younger. Symptom scores bore no relation to either specific IgE or IgG antibodies. Side‐effects were mainly local and were equal in both groups.

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Problems in allergen standardization

1985

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Specific sensitivity to individual grass pollens in some hay fever patients

Abstract: It has been shown in a series of 338 hay fever sufferers that about 19% give one or more (up to nine) negative skin test reactions when tested by the prick test technique to extracts of the pollens of twelve of the most widespread British grasses.

Cited by 9 publications

References 2 publications

In vitro diagnosis of atopic allergy The occurrence and clustering of positive RAST results as a function of age and total IgE concentration

In vitro diagnosis of atopic allergy The occurrence and clustering of positive RAST results as a function of age and total IgE concentration

A comparison of the clinical and immunological effects of an alum‐precipitated five‐grass extract with a conjugated two‐grass extract in the desensitization of hay fever

Problems in allergen standardization

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