5Vector-borne flaviviruses are emerging threats to human health. For successful 3 6 transmission, the virus needs to efficiently enter mosquito cells, replicate within, and 3 7 escape several tissue barriers while mosquitoes elicit major transcriptional responses to 3 8 flavivirus infection. This process will not only be affected by the specific mosquito-3 9 pathogen pairing, but also variation in key environmental variables such as temperature. 4 0 Thus far, few studies have examined the molecular responses triggered by temperature 4 1 and how these responses modify infection outcomes despite substantial evidence 4 2 showing strong relationships between temperature and transmission in a diversity of 4 3 systems. To define the host transcriptional changes associated with temperature 4 4 variation during the early infection process, we compared the transcriptome of mosquito 4 5midgut samples from mosquitoes exposed to Zika virus (ZIKV) and non-exposed 4 6 mosquitoes housed at three different temperatures (20, 28, and 36°C). While the high 4 7 temperature samples did not have significant changes from standard rearing conditions 4 8 These temperature constraints on infection are likely regulated through different 1 3 2 mechanisms. Temperature variation in general could profoundly impact arbovirus
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