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The possible role of cGMP in the regulation of the extinction of the reactions of the RPa4, RPa3, and LPa3 neurons of the edible snail in response to acetylcholine (ACh), applied rhythmically to the soma of the neuron by means of microiontophoresis, has been investigated. It was demonstrated that activators of guanylate cyclase which increased the level of cGMP in the cell, namely, sodium nitroprusside and sodium azide (5.10(-4)-10(-3) mole/liter), when applied intracellularly, intensify the extinction of inward transmembrane current and of depolarization of the membrane in response to ACh. The hypothesis of the participation of cGMP-dependent phosphorylation of membrane proteins in the regulation of the rate of development, depth, and duration of short-lived plasticity of the cholinoreceptors of the neuron is proposed.

The article presents the results of molecular-genetic investigation of isolates of rabies virus was isolated from 2 rabies patients in Ukraine. It has been confirmed that the virus that caused the deaths belongs to animal lyssavirus, namely the rabies virus. It has been proved that street isolates from humans by their genetic characteristics belong to the first genotype (RABV), the first phylogroup of animal lyssavirus. High homology between experimental samples and materials from cats, dogs, and foxes from the territory of Ukraine and with isolates in fox populations in South-Eastern Europe was revealed. RT-PCR confirmed that 2 people died of rabies, the isolates belong to the first phylogroup of lissavirus, the first genotype (RABV). It is proved that 2 street isolates from people from Ukraine are similar in degree of homology to the isolates isolated in fox populations in South-Eastern Europe.

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