Identification of cholinoreceptors on the soma of snail neurons RPa3 and LPa3

Pivovarov, A. S.; Drozdova, E. I.

doi:10.1007/bf01053484

Cited by 8 publications

(8 citation statements)

References 3 publications

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“…We previously identified extrasynaptic nicotinic and muscarinic receptors on the soma of command neurons LPa3 and PPa3 in edible snail [4,5]. These data indicate that nicotinic and muscarinic receptors are localized not only in the extrasynaptic zone of the membrane in command neurons of edible snail, but also in the subsynaptic region.…”

Section: Resultsmentioning

confidence: 86%

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Cholinergic sensory inputs to command neurons in edible snail

2006

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We studied cholinergic component of visceral sensory input to defensive behavior command neurons in edible snail. Nicotinic receptor antagonist tubocurarine and muscarinic receptor antagonist atropine reversibly decreased the amplitude of the total excitatory postsynaptic potential induced by electrostimulation of the peripheral region in the mechanosensory receptor field of command neurons on the surface of internal organs. Our results indicate that acetylcholine is involved in sensory signal transduction from the visceral sac to command neurons of snail parietal ganglia. The subsynaptic membrane of visceral synaptic input contains nicotinic and muscarinic receptors.

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Section: Resultsmentioning

confidence: 86%

“…Extrasynaptic somatic cholinoceptors of the nicotinic and muscarinic types were pharmacologically identified. Muscarinic receptors differ from M1 and M2 subtypes [5]. Studies of the isolated soma of command neurons revealed cholinergic sensitivity of their somatic membrane [1].…”

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confidence: 99%

Cholinergic sensory inputs to command neurons in edible snail

2006

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“…Since defensive behavior command neurons of edible snail have both extrasynaptic [5] and postsynaptic [4,7] cholinoceptors, up-regulation of cholinoceptors recycling can increase the efficiency of interneuronal traffic for a short period during sensitization of the defensive reflex by elevation of sensitivity of the extrasynaptic and probably subsynaptic membrane regions to the neurotransmitter without synthesis of new transmitter receptors. This work was supported by the Russian Foundation for Basic Research, grant No.…”

Section: Resultsmentioning

confidence: 99%

“…Acetylcholine (Ach) was applied locally by ionophoresis to the dorsal surface of neuron soma at the rate of 10 -1 min. Transmembrane ionic current induced by local application of ACh (Ach-currents) were recorded [1,2,5,6].…”

Section: Methodsmentioning

confidence: 99%

Role of cholinoceptors recycling in short-term potentiation of cholinosensitivity of command neurons in edible snail

2007

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Exocytosis inhibitor Exo 1, dynamin inhibitory peptide (inhibitor of endocytosis), and colchicine disturb short-term potentiation of cholinosensitivity of defensive behavior command neurons in edible snail induced by rhythmic electrical orthodromic stimulation. We hypothesize that the short-term potentiation of cholinosensitivity in the extra-synaptic membrane develops due to incorporation of extra cholinoceptors into neuron plasmalemma as a result of enhanced recycling of the internalized cholinoceptors with participation of microtubules.

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“…The identification of CR on the soma of the RPa3 and LPa3 neurons was carried out with the aid of a larger number of cholinomimetics and cholinolytics, with the recording of transmembrane ionic currents by means of the method of two-electrode recording of the potential on the membrane [4]. The capacity of nicotinic (nicotine, cytisine) and muscarinic (muscarine, arecoline, pilocarpine, oxotremorine, and carbamyl choline) cholinomimetics to induce in a dose-dependant fashion the inward current of the RPa3 and LPa3 neurons of the snail offers the possibility of identifying the membrane centers bound by them on the soma as nicotinic and muscarinic.…”

Section: Identification Of Cholinoreceptorsmentioning

confidence: 99%

Cholinoreceptor neurons of the snail: Identification, plasticity, and its regulation by opioids and second messengers

Pivovarov

1994

Neurosci Behav Physiol

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A review of the author's own data on the cholinoreceptors of identified neurons of the snail and the regulation of their plasticity. The following sections are presented: the identification of the cholinoreceptors; the coupling of the cholinoreceptors with ion channels; the identification of the opioid receptors; the modulation by opioids of the activity of the cholinoreceptors; the plasticity of the cholinoreceptors; the regulation of the plasticity of the cholinoreceptors by opioids; the regulation of the plasticity of the cholinoreceptors by second messengers; the second messengers involved in the regulation of the plasticity of the cholinoreceptors by the opiate kappa agonist, bremazocine.

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Identification of cholinoreceptors on the soma of snail neurons RPa3 and LPa3

Cited by 8 publications

References 3 publications

Cholinergic sensory inputs to command neurons in edible snail

Cholinergic sensory inputs to command neurons in edible snail

Role of cholinoceptors recycling in short-term potentiation of cholinosensitivity of command neurons in edible snail

Cholinoreceptor neurons of the snail: Identification, plasticity, and its regulation by opioids and second messengers

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