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The search for new sources of effective and low-toxicity biologically active substances, including natural materials and products, has received much attention in recent years. An important source of this type is offered by the products of beekeeping: more than 400 therapeutic and prophylactic preparations based on these products are available abroad and many of them have been successfully used for the prophylaxis and treatment of various disorders [1]. Unfortunately, the nomenclature of domestic preparations of this kind includes only several positions, which is explained by the lack of commercial technologies for processing the products of beekeeping and the absence of research and development programs aimed at the development of such preparations and the corresponding technologies.In order to fill this gap, we perform systematic investigations of the chemical composition and biological activity of bee brood, a nontraditional product of beekeeping comprising a mixture of bee queen, worker, and drone larvae, prepupas, and pupas. As is known, the chemical composition of bee brood is close to that of bee milk [2,3]. In this context, it was of interest to determine the content of lipid phosphorus and phospholipids -important biologically active components of bee milk -in various types of bee brood.We have also studied variations in the content of lipid phosphorus and phospholipids as dependent on the geographic site, bee species, and climate (such a dependence was established for the bee milk components). These species 517 0091-150X/04/3809-0517

The search for new sources of effective and low-toxicity biologically active substances, including natural materials and products, has received much attention in recent years. An important source of this type is offered by the products of beekeeping: more than 400 therapeutic and prophylactic preparations based on these products are available abroad and many of them have been successfully used for the prophylaxis and treatment of various disorders [1]. Unfortunately, the nomenclature of domestic preparations of this kind includes only several positions, which is explained by the lack of commercial technologies for processing the products of beekeeping and the absence of research and develop-ment programs aimed at the development of such preparations and the corresponding technologies.In order to fill this gap, we perform systematic investigations of the chemical composition and biological activity of bee brood, a nontraditional product of beekeeping comprising a mixture of bee queen, worker, and drone larvae, prepupas, and pupas. As is known, the chemical composition of bee brood is close to that of bee milk [2,3]. In this context, it was of interest to determine the content of lipid phosphorus and phospholipids -important biologically active components of bee milk -in various types of bee brood.We have also studied variations in the content of lipid phosphorus and phospholipids as dependent on the geographic site, bee species, and climate (such a dependence was established for the bee milk components). These species 517 0091-150X/04/3809-0517

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